Welcome to the European Association for Cancer Research
Connecting cancer researchers together
Mechanisms to Therapies: Innovations in Cancer Metabolism
Bilbao, Spain : 9 - 11 October 2018
Scientific Programme
FULL PROGRAMME AND SPEAKER ABSTRACTS
Click here to download the Full Programme and Abstract Book for the course.
Registration
Until 11:30
Coffee available
Conference Welcome
Scientific Programme Committee
ASEICA Keynote Lecture
Chair: Navdeep Chandel
William Kaelin, Jr. Howard Hughes Medical Institute and Dana-Farber Cancer Institute, USA
"The VHL Tumor Suppressor: Insights into Oxygen Sensing, Cancer Metabolism, and Drugging the Undruggable"
Session 1 - Oncogenic metabolic signalling
Chair: Ayelet Erez
Brendan Manning Harvard T.H. Chan School of Public Health, USA
"The PI3K-mTOR Signaling Network and the Anabolic Control of Cell Growth"
LUNCH & MEET THE EXPERT
Alejo Efeyan CNIO, Spain
"Oncogenic nutrient signalling in B cell lymphoma"
Reuben Shaw The Salk Institute, USA
"AMPK: good signals during bad times"
Heather Christofk UCLA Jonsson Comprehensive Cancer Center, USA
"Metabolic Transitions in Cancer: Lessons from Viral Infection"
Mattia Falcone DKFZ, Germany
Proffered Paper 1: "BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation"
COFFEE BREAK
Session 2 - Metabolic wiring in cancer
Chair: Salvador Aznar-Benitah
Sarah-Maria Fendt VIB-KU Leuven Center for Cancer Biology, Belgium
"Nutrient metabolism in cancer progression"
Ayelet Erez Weizmann Institute of Science, Israel
"The contribution of urea cycle enzymes and intermediates to carcinogenesis"
Matt Vander Heiden Massachusetts Institute of Technology, USA
"How metabolisum supports tumour progression"
Javier Garcia Bermudez The Rockefeller University, USA
Proffered Paper 2: "Exploiting Cholesterol Auxotrophy of Lymphomas as an Anti-Cancer Therapy"
Session 3 - Metabolic control of the epigenome
Chair: Sarah-Maria Fendt
Raul Mostoslavsky MGH Cancer Center, Harvard Medical School, USA
"Linking metabolism, chromatin and cancer: SIRT6 provides new clues"
Jason Locasale Duke University School of Medicine, USA
"Glucose and amino acid metabolism in cancer"
Andrew Intlekofer MSKCC, USA
Proffered Paper 3: "Mechanisms of acquired resistance to mutant isocitrate dehydrogenase inhibitors"
EXHIBITOR INTRODUCTIONS
A fun session to introduce the companies who are exhibiting at the conference
COFFEE BREAK
Trade exhibition opens
Oliver Maddocks University of Glasgow, UK
"(Non)Essential Amino Acid Metabolism In Cancer"
Navdeep Chandel Northwestern University, USA
"Mitochondria as signaling organelles"
POSTER SPOTLIGHTS
Six top-scoring abstracts will be presented in short 'flash talks' of 3 minutes each.
LUNCH & POSTER DEFENCE SESSION 1
Odd numbered posters (1, 3, 5, etc.) will be presented
Session 4 -Metabolic heterogeneity & tumour progression
Chair: Matt Vander Heiden
Salvador Aznar-Benitah ICREA, IRB Barcelona, Spain
"Epigenetic influence of our (fatty) diet on metastatic-initiating cells"
Arkaitz Carracedo CIC bioGUNE, Spain
"Metabolic plasticity in the ever-changing tumor environment"
Cristina Muñoz-Pinedo IDIBELL, Spain
Proffered Paper 4: "Starvation leads to inflammatory cytokine and chemokine release"
COFFEE BREAK
Carla Martins University of Cambridge, UK
"Metabolic dependencies of mutant Kras lung tumors"
Thales Papagiannakopoulos NYU School of Medicine, USA
"Uncovering metabolic bottlenecks in lung cancer"
Meet the Editor
Javier Carmona Senior Editor at Nature Medicine, Nature
This is an informal session for PhD students and post-docs who want to learn more about a career as an editor. Spaces are limited, and sign up will open after the registration deadline.
Optional Conference Dinner
Kafe Antzokia
Peter Carmeliet VIB-KU Leuven Center for Cancer Biology, Belgium
"Angiogenesis revisited: Role and (therapeutic) implications of endothelial metabolism"
Session 5 - Targeting stroma metabolism
Chair: Heather Christofk
Susan Kaech The Salk Institute, USA
"Anti-Tumor T Cells – you are what you eat"
Kathrin Renner University Hospital Regensburg, Germany
"Targeting glycolysis via inhibition of MCT1 and MCT4 preserves T cell effector functions and augments checkpoint therapy"
Patricia Sancho IIS, Spain
Proffered Paper 5: "Metabolic switch controlled by MYC/PGC1A is a prerequisite for epithelial-to-mesenchymal transition and metastasis in pancreatic cancer"
COFFEE BREAK
Session 6 - Bench to bedside/ Targeting metabolic liabilities
Chair: Brendan Manning
Judith Favier INSERM, France
"Epigenetic and metabolic reprogramming in SDH-deficient cancers"
Alec Kimmelman Perlmutter Cancer Center, USA
"Identifying Metabolic Dependencies in Pancreatic Cancer"
Ivana Kurelac University of Bologna, Italy
Proffered Paper 6: "Inducing indolence in aggressive cancers by targeting mitochondrial complex I is counteracted by macrophage-mediated adaptive responses"
LUNCH & POSTER DEFENCE SESSION 2
Even numbered posters (2, 4, 6, etc.) will be presented
Scott Biller Agios, USA
"Cancer Metabolism from Bench to the Clinic"
EMBO Keynote Lecture
Chair: Ralph DeBerardinis
Karen Vousden The Francis Crick Institute, UK
"p53 and metabolism: cancer and beyond"
CLOSING CEREMONY & PRESENTATION OF AWARD CERTIFICATES
Until 16:00
Scientific Programme Committee
Key dates
Travel Grant application deadline:
22 July 2018
Abstract submission deadline:
22 July 2018
Registration and Payment deadline:
09 September 2018
