Registration

Until 11:30

Coffee available

Conference Welcome

Scientific Programme Committee

ASEICA Keynote Lecture

Chair: Navdeep Chandel

William Kaelin, Jr. Howard Hughes Medical Institute and Dana-Farber Cancer Institute, USA

"The VHL Tumor Suppressor: Insights into Oxygen Sensing, Cancer Metabolism, and Drugging the Undruggable"

Session 1 - Oncogenic metabolic signalling

Chair: Ayelet Erez

Brendan Manning Harvard T.H. Chan School of Public Health, USA

"The PI3K-mTOR Signaling Network and the Anabolic Control of Cell Growth"

LUNCH & MEET THE EXPERT

Alejo Efeyan CNIO, Spain

"Oncogenic nutrient signalling in B cell lymphoma"

Reuben Shaw The Salk Institute, USA

"AMPK: good signals during bad times"

Heather Christofk UCLA Jonsson Comprehensive Cancer Center, USA

"Metabolic Transitions in Cancer: Lessons from Viral Infection"

Mattia Falcone DKFZ, Germany

Proffered Paper 1: "BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation"

COFFEE BREAK

Session 2 - Metabolic wiring in cancer

Chair: Salvador Aznar-Benitah

Sarah-Maria Fendt VIB-KU Leuven Center for Cancer Biology, Belgium

"Nutrient metabolism in cancer progression"

Ayelet Erez Weizmann Institute of Science, Israel

"The contribution of urea cycle enzymes and intermediates to carcinogenesis"

Matt Vander Heiden Massachusetts Institute of Technology, USA

"How metabolisum supports tumour progression"

Javier Garcia Bermudez The Rockefeller University, USA

Proffered Paper 2: "Exploiting Cholesterol Auxotrophy of Lymphomas as an Anti-Cancer Therapy"

Session 3 - Metabolic control of the epigenome

Chair: Sarah-Maria Fendt

Raul Mostoslavsky MGH Cancer Center, Harvard Medical School, USA

"Linking metabolism, chromatin and cancer: SIRT6 provides new clues"

Jason Locasale Duke University School of Medicine, USA

"Glucose and amino acid metabolism in cancer"

Andrew Intlekofer MSKCC, USA

Proffered Paper 3: "Mechanisms of acquired resistance to mutant isocitrate dehydrogenase inhibitors"

EXHIBITOR INTRODUCTIONS

A fun session to introduce the companies who are exhibiting at the conference

COFFEE BREAK

Trade exhibition opens

Oliver Maddocks University of Glasgow, UK

"(Non)Essential Amino Acid Metabolism In Cancer"

Navdeep Chandel Northwestern University, USA

"Mitochondria as signaling organelles"

POSTER SPOTLIGHTS

Six top-scoring abstracts will be presented in short 'flash talks' of 3 minutes each.

LUNCH & POSTER DEFENCE SESSION 1

Odd numbered posters (1, 3, 5, etc.) will be presented

Session 4 -Metabolic heterogeneity & tumour progression

Chair: Matt Vander Heiden

Salvador Aznar-Benitah ICREA, IRB Barcelona, Spain

"Epigenetic influence of our (fatty) diet on metastatic-initiating cells"

Arkaitz Carracedo CIC bioGUNE, Spain

"Metabolic plasticity in the ever-changing tumor environment"

Cristina Muñoz-Pinedo IDIBELL, Spain

Proffered Paper 4: "Starvation leads to inflammatory cytokine and chemokine release"

COFFEE BREAK

Carla Martins University of Cambridge, UK

"Metabolic dependencies of mutant Kras lung tumors"

Thales Papagiannakopoulos NYU School of Medicine, USA

"Uncovering metabolic bottlenecks in lung cancer"

Meet the Editor

Javier Carmona Senior Editor at Nature Medicine, Nature

This is an informal session for PhD students and post-docs who want to learn more about a career as an editor. Spaces are limited, and sign up will open after the registration deadline.

Optional Conference Dinner

Kafe Antzokia

Peter Carmeliet VIB-KU Leuven Center for Cancer Biology, Belgium

"Angiogenesis revisited: Role and (therapeutic) implications of endothelial metabolism"

Session 5 - Targeting stroma metabolism

Chair: Heather Christofk

Susan Kaech The Salk Institute, USA

"Anti-Tumor T Cells – you are what you eat"

Kathrin Renner University Hospital Regensburg, Germany

"Targeting glycolysis via inhibition of MCT1 and MCT4 preserves T cell effector functions and augments checkpoint therapy"

Patricia Sancho IIS, Spain

Proffered Paper 5: "Metabolic switch controlled by MYC/PGC1A is a prerequisite for epithelial-to-mesenchymal transition and metastasis in pancreatic cancer"

COFFEE BREAK

Session 6 - Bench to bedside/ Targeting metabolic liabilities

Chair: Brendan Manning

Judith Favier INSERM, France

"Epigenetic and metabolic reprogramming in SDH-deficient cancers"

Alec Kimmelman Perlmutter Cancer Center, USA

"Identifying Metabolic Dependencies in Pancreatic Cancer"

Ivana Kurelac University of Bologna, Italy

Proffered Paper 6: "Inducing indolence in aggressive cancers by targeting mitochondrial complex I is counteracted by macrophage-mediated adaptive responses"

LUNCH & POSTER DEFENCE SESSION 2

Even numbered posters (2, 4, 6, etc.) will be presented

Scott Biller Agios, USA

"Cancer Metabolism from Bench to the Clinic"

EMBO Keynote Lecture

Chair: Ralph DeBerardinis

Karen Vousden The Francis Crick Institute, UK

"p53 and metabolism: cancer and beyond"

CLOSING CEREMONY & PRESENTATION OF AWARD CERTIFICATES

Until 16:00

Scientific Programme Committee