Mechanisms to Therapies: Innovations in Cancer Metabolism

Bilbao, Spain : 9 - 11 October 2018

Scientific Programme

Tuesday 9th October 2018

10:30

Registration

Until 11:30

Coffee available

11:30

Conference Welcome

Scientific Programme Committee

11:45

ASEICA Keynote Lecture

Chair: Navdeep Chandel

William Kaelin, Jr. Howard Hughes Medical Institute and Dana-Farber Cancer Institute, USA

"The VHL Tumor Suppressor: Insights into Oxygen Sensing, Cancer Metabolism, and Drugging the Undruggable"

Session 1 - Oncogenic metabolic signalling

Chair: Ayelet Erez

12:30

Brendan Manning Harvard T.H. Chan School of Public Health, USA

"The PI3K-mTOR Signaling Network and the Anabolic Control of Cell Growth"

13:00

LUNCH & MEET THE EXPERT

14:30

Alejo Efeyan CNIO, Spain

"Oncogenic nutrient signalling in B cell lymphoma"

15:00

Reuben Shaw The Salk Institute, USA

"AMPK: good signals during bad times"

15:30

Heather Christofk UCLA Jonsson Comprehensive Cancer Center, USA

"Metabolic Transitions in Cancer: Lessons from Viral Infection"

16:00

Mattia Falcone DKFZ, Germany

Proffered Paper 1: "BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation"

16:15

COFFEE BREAK

Session 2 - Metabolic wiring in cancer

Chair: Salvador Aznar-Benitah

16:45

Sarah-Maria Fendt VIB-KU Leuven Center for Cancer Biology, Belgium

"Nutrient metabolism in cancer progression"

17:15

Ayelet Erez Weizmann Institute of Science, Israel

"The contribution of urea cycle enzymes and intermediates to carcinogenesis"

17:45

Matt Vander Heiden Massachusetts Institute of Technology, USA

"How metabolisum supports tumour progression"

18:15

Javier Garcia Bermudez The Rockefeller University, USA

Proffered Paper 2: "Exploiting Cholesterol Auxotrophy of Lymphomas as an Anti-Cancer Therapy"

Wednesday 10th October 2018

Session 3 - Metabolic control of the epigenome

Chair: Sarah-Maria Fendt

09:30

Raul Mostoslavsky MGH Cancer Center, Harvard Medical School, USA

"Linking metabolism, chromatin and cancer: SIRT6 provides new clues"

10:00

Jason Locasale Duke University School of Medicine, USA

"Glucose and amino acid metabolism in cancer"

10:30

Andrew Intlekofer MSKCC, USA

Proffered Paper 3: "Mechanisms of acquired resistance to mutant isocitrate dehydrogenase inhibitors"

10:45

EXHIBITOR INTRODUCTIONS

A fun session to introduce the companies who are exhibiting at the conference

10:50

COFFEE BREAK

Trade exhibition opens

11:20

Oliver Maddocks University of Glasgow, UK

"(Non)Essential Amino Acid Metabolism In Cancer"

11:50

Navdeep Chandel Northwestern University, USA

"Mitochondria as signaling organelles"

12:20

POSTER SPOTLIGHTS

Six top-scoring abstracts will be presented in short 'flash talks' of 3 minutes each.

12:50

LUNCH & POSTER DEFENCE SESSION 1

Odd numbered posters (1, 3, 5, etc.) will be presented

Session 4 -Metabolic heterogeneity & tumour progression

Chair: Matt Vander Heiden

14:50

Salvador Aznar-Benitah ICREA, IRB Barcelona, Spain

"Epigenetic influence of our (fatty) diet on metastatic-initiating cells"

15:20

Arkaitz Carracedo CIC bioGUNE, Spain

"Metabolic plasticity in the ever-changing tumor environment"

15:50

Thales Papagiannakopoulos NYU School of Medicine, USA

Proffered Paper 4: "Uncovering metabolic bottlenecks in lung cancer"

16:05

COFFEE BREAK

16:35

Carla Martins University of Cambridge, UK

"Metabolic dependencies of mutant Kras lung tumors"

17:05

Celeste Simon University of Pennsylvania, USA

“Inflammation, Metabolism, and Tumor Progression”

17:35

Meet the Editor

Javier Carmona Senior Editor at Nature Medicine, Nature

This is an informal session for PhD students and post-docs who want to learn more about a career as an editor. Spaces are limited, and sign up will open after the registration deadline.

20:30

Optional Conference Dinner

Kafe Antzokia

Thursday 11th October 2018

Session 5 - Targeting stroma metabolism

Chair: Heather Christofk

09:00

Peter Carmeliet VIB-KU Leuven Center for Cancer Biology, Belgium

"Angiogenesis revisited: Role and (therapeutic) implications of endothelial metabolism"

09:30

Susan Kaech The Salk Institute, USA

"Anti-Tumor T Cells – you are what you eat"

10:00

Marina Kreutz University Hospital Regensburg, Germany

"Targeting glycolysis via inhibition of MCT1 and MCT4 preserves T cell effector functions and augments checkpoint therapy"

10:30

Patricia Sancho IIS, Spain

Proffered Paper 5: "Metabolic switch controlled by MYC/PGC1A is a prerequisite for epithelial-to-mesenchymal transition and metastasis in pancreatic cancer"

10:45

COFFEE BREAK

Session 6 - Bench to bedside/ Targeting metabolic liabilities

Chair: Brendan Manning

11:15

Ralph DeBerardinis Children’s Medical Center Research Institute, USA

"Metabolic complexity in cancer cells and tumors"

11:45

Alec Kimmelman Perlmutter Cancer Center, USA

"Identifying Metabolic Dependencies in Pancreatic Cancer"

12:15

Ivana Kurelac University of Bologna, Italy

Proffered Paper 6: "Inducing indolence in aggressive cancers by targeting mitochondrial complex I is counteracted by macrophage-mediated adaptive responses"

12:30

LUNCH & POSTER DEFENCE SESSION 2

Even numbered posters (2, 4, 6, etc.) will be presented

14:30

Scott Biller Agios, USA

"Cancer Metabolism from Bench to the Clinic"

15:00

EMBO Keynote Lecture

Chair: Ralph DeBerardinis

Karen Vousden The Francis Crick Institute, UK

"p53 and metabolism: cancer and beyond"

15:45

CLOSING CEREMONY & PRESENTATION OF AWARD CERTIFICATES

Until 16:00

Scientific Programme Committee

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