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Welcome to the European Association for Cancer Research
Europe’s membership association for cancer researchers
Radiation Break-through: from DNA damage responses to precision cancer therapy
Oxford, UK : 12 - 14 March 2018
Scientific Programme
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FULL PROGRAMME AND SPEAKER ABSTRACTS
Click here to download the Full Programme and Abstract Book for the conference.
Registration
Wolfson College foyer
tea/coffee will be available in the Haldane Room
Light Lunch
Haldane Room
Conference Welcome
Leonard Wolfson Auditorium
Scientific Programme Committee
Session 1 - DDR & DNA repair
Session Chair: Jos Jonkers
Opening Lecture
Steve Jackson University of Cambridge, UK
"Cellular responses to DNA damage: mechanistic insights and therapeutic applications"
Alessandro A. Sartori University of Zurich, Switzerland
"Exploiting cell-penetrating peptide inhibitors of homologous recombination as research tools and as novel cancer therapeutics"
Sylvie Noordermeer Leiden University Medical Centre, Netherlands
Proffered Paper 1: "Identification of the Shieldin complex as a novel effector of 53BP1-dependent DNA repair"
Karlene Cimprich Stanford University School of Medicine, USA
"ATR couples DNA replication and mitosis through an S/G2 phosphorylation switch and transcription program"
COFFEE BREAK
Hall
Anton Gartner University of Dundee, UK
Proffered Paper 2: "Massive C. elegans whole-genome sequencing for profiling mutational signatures associated with IR, carcinogens and DNA repair deficiency"
Madalena Tarsounas CRUK/MRC Oxford Institute for Radiation Oncology, UK
"A pharmacological screen identifies drugs that selectively target BRCA1/2-deficiency and counteract drug resistance"
Christian Reinhardt University Hospital Cologne, Germany
"Targeting defects in the DNA damage response to treat tumors driven by non-druggable oncogenes"
Nina Gustafsson Karolinska Institute, Sweden
Proffered Paper 3: "Protecting the genome through metabolic enzymes"
EXHIBITOR INTRODUCTIONS
A fun session to introduce the companies who are exhibiting at the conference
Welcome buffet and Drinks
Haldane Room & Hall
Opening of the trade exhibition
POSTER DEFENCE SESSION 1
The Haldane Room & Hall
until 20:45
POSTER VIEWING
Haldane Room & Hall
Tea/coffee will be available
Session 2 - Biomarkers & Tissue Responses to Radiation (1)
Session Chair: Karlene Cimprich
Jos Jonkers Netherlands Cancer Institute (NKI), Netherlands
"Identification of cancer drivers and mechanisms of therapy resistance in mouse models of BRCA-deficient breast cancer"
Claus Sørensen BRIC, Denmark
"Cancer cell evasion of growth limits imposed by genotoxic stress"
Flavie Coquel Institut de Génétique Humaine, France
Proffered Paper 4: "SAMHD1 acts at stalled replication forks to prevent ssDNA-mediated induction of type I interferons"
Ludwig Dubois Maastricht University, Netherlands
"Radiotherapy and immunotherapy: partners in crime"
COFFEE BREAK
Hall
Jason Parsons University of Liverpool, UK
Proffered Paper 5: "Complex DNA damage induced by high-LET protons triggers a specific cellular DNA damage response"
Verena Jendrossek University of Duisburg-Essen, Germany
"Radiation-induced normal tissue toxicity: new insight from damage signaling and tissue-specific immune defense strategies"
SEATED LUNCH
Haldane Room & Buttery
Session 3 - Biomarkers & Tissue Responses to Radiation (2)
Session Chair: Martin Pruschy
Catharine West University of Manchester, UK
"Radiobiology Biomarkers for Precision Radiotherapy"
Anderson Ryan University of Oxford, UK
"The impact of DNA damage response (DDR) modulators on normal tissues following thoracic irradiation in preclinical models"
Domenico Maiorano Institute of Human Genetics, France
Proffered Paper 6: "Targeting the RAD18 ubiquitin ligase enhances sensitivity to therapy by inhibiting cancer stem cells proliferation"
Andrew Tutt The Institute of Cancer Research (ICR), UK
"Understanding genomic instability and targeting defective DNA damage responses in breast cancer"
Meet the Experts Session
with Madalena Tarsounas, Verena Jendrossek and Karlene Cimprich
POSTER DEFENCE SESSION 2
Haldane Room & Hall
until 18:00
Conference Dinner
Cherwell Boathouse
Pre-booked optional extra
POSTER VIEWING
Haldane Room & Hall
Tea/coffee will be available
Session 4 - Translational
Session Chair: Madalena Tarsounas
Timothy Humphrey CRUK/MRC Oxford Institute for Radiation Oncology, UK
"Targeting histone H3K36me3-deficient cancers"
Frank Pajonk UCLA, USA
"Cancer Therapies and Cancer Cell Plasticity"
Olivier De Wever Ghent University, Belgium
Proffered Paper 7: "Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1R activation"
COFFEE BREAK
Hall
Brita Singers Sorensen Aarhus University, Denmark
"Implementation and Validation of a 15-Gene Hypoxia Classifier in Head and Neck Cancer"
Martin Pruschy University Hospital Zürich, Switzerland
"Targeting the secretome as part of combined treatment modalities with radiotherapy"
Closing Lecture
Amato Giaccia Stanford University School of Medicine, USA
"Protecting normal tissue from DNA damage to enhance the efficacy of radiotherapy"
CLOSING SUMMARY
Poster Prizes and Meeting Bursaries will be presented by Verena Jendrossek
LUNCH & DEPART
Haldane Room
Key dates
Bursary application deadline:
15 January 2018
Abstract submission deadline:
22 January 2018
Registration deadline:
12 February 2018
Lecture theatre at Wolfson College.
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