Welcome to the European Association for Cancer Research
Connecting cancer researchers together
EACR-AstraZeneca Virtual Conference ‘Drug Tolerant Persister Cells’
Virtual Event, Worldwide : 7 - 8 December 2021
Scientific Programme
To download and print the programme, use the links below.
Listed times are in Central European Time (CET)
Welcome to Day One
Alberto Bardelli
Session 1 - Biology of persister cells
Co-Chairs: Alberto Bardelli, Ultan McDermott and Caroline Robert
Nathalie Balaban The Hebrew University of Jerusalem, Israel
"Persistence under treatment: from bacteria to mammalian cells"
Q&A 13:30 - 13:50
Mariangela Russo University of Torino, Italy
"Adaptive mutability favors the evolution of secondary resistance in cancer persister cells"
Q&A: 14:10 - 14:30
Transition break
Chewei Anderson Chang University of Toronto, Canada
Proffered Paper 1: "Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer"
Q&A: 14:45 - 14:55
Anna Golebiewska Luxembourg Institute of Health, Luxembourg
Proffered Paper 2: "Phenotypic heterogeneity and plasticity as resistance mechanisms in Glioblastoma"
Q&A: 15:05 - 15:15
Transition break
Yaara Oren Broad Institute, Cambridge, USA
"Using Watermelons to uncover adaptations of cancer persister cells''
Q&A: 15:40 - 16:00
Refreshment break
Alix Le Marois Francis Crick Institute, UK
Proffered Paper 3: "Imaging drug resistance: using fluorescent biosensors of oncogenic signalling to understand therapy response in EGFR-mutant Non-Small Cell Lung Cancer."
Q&A: 16:25 -16:35
Derek B. Oien AstraZeneca, USA
Proffered Paper 4: "Therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells"
Q&A: 16:45 - 16:55
Transition break
Catherine O'Brien University of Toronto, Canada
"Targeting the diapause-like drug tolerant persister state in colorectal cancer"
Q&A: 17:20 - 17:40
Poster Spotlights
3 top abstracts presented as 3 minute flash talks
Let's gather together in 'Gather'
An informal opportunity for participants to browse the posters and make new connections. After the end of the session 'Gather' will remain open until the end of the Conference.
Listed times are in Central European Time (CET)
Virtual Poster Discussion Session in Gather
Welcome to Day Two
Rene Bernards
Session 2 - Novel targets in persister space
Co-Chairs: Rene Bernards and Paul Smith
Chris Marine VIB KU Leuven Center for Cancer Biology, Leuven, Belgium
"Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma"
Q&A: 14:25 - 14:45
Transition break
Isabel Puig Vall d'Hebron Institute of Oncology, Spain
Proffered Paper 5: "Deciphering slow-cycling cancer cells to break down the wall of therapy resistance."
Q&A: 15:00 - 15:10
Ravid Straussman Weizmann institute, Israel
Proffered Paper 6: "IRS1 phosphorylation determines a heritable probability of cancer cells to persist during EGFR inhibition therapy"
Q&A: 15:20 - 15:30
Transition break
Pasi Janne Dana-Farber Cancer Institute, Boston, USA
“Treatment of targeted therapy induced drug persistent disease in lung cancer”
Q&A: 15:55 - 16:15
Refreshment break
Trever Bivona The Bivona Lab
"Integrative mechanisms underlying drug tolerance in oncogene-driven lung cancer"
Q&A: 16:50 - 17:10
Transition break
Alexander van Oudenaarden Hubrecht Institute, Utrecht, Netherlands
"Novel single-cell sequencing tools to explore (persister) cells in space and time"
Q&A: 17:35 - 17:55
Transition break
Discussion Forum 'How to best kill DTPs'
Paul Smith to Chair with 10 minute introduction
Summary and End of Day Two
