EACR Industry Webinar with Illumina-sponsored speaker "Multiomic profiling of patient-derived subclones identifies aggressive cellular subpopulations in paediatric diffuse high-grade gliomas (PDHGGs)"

Virtual Event, Worldwide

1 February 2023

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17:00 CET / 09:00 PST on Zoom

This free webinar is hosted in collaboration with Illumina, one of our valued EACR Industry Partners. We are delighted to welcome Ketty Kessler and Sujash Chatterjee who will discuss how recent advances in single-cell methodologies and multiomic profiling enables an unprecedent insight into heterogenous tumours: PDHGGs.

Talk Abstract

Ketty Kessler, PhD, Postdoctoral Fellow, Institute of Cancer Research, London
“Multiomic profiling of patient-derived subclones identifies aggressive cellular subpopulations in paediatric diffuse high-grade gliomas (PDHGGs)”
Recent advances in single-cell methodologies and multiomic profiling enables gaining an unprecedent insight into heterogenous tumours: PDHGGs. These incurable tumours classify into distinct subgroup based upon their location and defining molecular alterations. In our patient-derived models, we identified an aggressive subpopulation defined by gene and protein expression profiles, secreted proteins, and chromatin configuration changes at key oncogenic loci such as FOS. A trans-histone mechanism driven by the methyltransferase (KMT5B) loss to lead to differential cis-regulation of genes involved in cell invasion/migration. Application of functionally-defined interventional strategies aimed at disrupting the interactions between these subpopulations may offer a novel therapeutic approach.

with introduction from Sujash Chatterjee, PhD, Global Cancer Research Lead at Illumina “Unraveling Cancer’s Complexity With Multiomics”.

Speaker Bios

Ketty Kessler completed her PhD in Molecular and Cellular biology at the Sorbonne Paris Cite University in 2014 and began studying paediatric brain cancer as a postdoctoral research associate at the University College London with Professor Salomoni. Since 2017, she is a postdoctoral research fellow working with Professor Jones at the Institute of Cancer Research in London, United Kingdom.

Sujash Chatterjee has over 15 years of experience in genomic profiling methods including microarrays/RNA-seq, assay development, and molecular/ cell biology techniques. He currently is the Global Marketing Manager for Illumina’s Cancer Research Segment team. Previously he was part of development and marketing teams for NGS products focused on Biomarker Discovery and HT Single Cell Sequencing. In his former role as Asst. Director for Science and Engineering Research Center at University of Houston, he built and led an NGS Core team that contributed to projects including: The Cancer Genome Atlas (NIH-TCGA) and NASA’s first single cell studies. In 2011, Sujash received his PhD from NYU Center for Genomics and Systems Biology.

Open to all, you do not need to be an EACR member to attend.

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