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Europe’s membership association for cancer researchers


Image of the Month: August 2017

The EACR Image of the Month highlights both scientifically and visually stunning cancer research images.

We are delighted to share our August 2017 winning image from Sinéad Lindsay and Prof. Amanda McCann of the University College Dublin, Ireland. Sinéad captured this beautiful fluorescent image showing the interaction of extracellular vesicles (EVs) with potential recipient triple negative breast cancer (TNBC) cells.

We wish to thank our panel of reviewers for their help in selecting the winning image.

Are you an EACR member? Do you have a scientific image you’d like to share? Please visit our Image of the Month page to find out how to submit your image.

Winner: Cell to Cell Tweeting: Fluorescent visualisation of extracellular vesicle (EV)-mediated cell to cell communication in the tumour microenvironment

Fluorescent image shows the interaction of extracellular vesicles (EVs) (red) with potential recipient triple negative breast cancer (TNBC) cells. Extracellular vesicles (EVs) are known to contain functional RNA, protein and metabolites which, in recipient cells, can propagate the tumourigenic phenotype. The transport of these particles through the blood or lymphatic systems has been documented, their ability to induce angiogenesis and set up metastatic niches in distant sites around the body proven. Inhibiting the entry of these biologically functional particles into recipient cells or even their initial release from TNBC cells could be a novel way to stem the metastasis spread so common in TNBC. 

Note: MDA-MB-231 TNBC cancer cells stained with alpha-tubulin (A488 green), nuclei (DAPI blue), extracellular vesicles (DiI red)

Submitted by: Ms Sinéad Lindsay MSc and Prof Amanda McCann PhD, UCD School of Medicine, University College Dublin, Ireland and the UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Ireland.

11 Aug 2017

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