Do you have background in molecular, biochemical or chemical mechanisms yet are interested in translational medicine? Are you interested in taking your mechanistic findings rapidly to the bedside in an internationally renowned clinical research program? If so, a postdoctoral fellowship position supported by the NIH and Prostate Cancer Foundation is available in the laboratory of Dr. Nima Sharifi at Cleveland Clinic, Cleveland OH, USA.
We focus on mechanistic discovery to understand metabolic and molecular mechanisms of androgen synthesis and androgen receptor gain-of-function that lead to resistance to hormonal therapy. Specific areas include:
We discovered the first gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Cell. 2013;154:1074-84). We also discovered that abiraterone treatment works by conversion to a more active steroidal metabolite (Nature. 2015;523:347-51), that metabolism is pharmacologically modifiable to optimize therapy (Nature. 2016;533:547-51), and that these events are a class effect of steroidal androgen synthesis inhibitors (Cell Chem Biol. 2017;24:825-32) and genetic determination of metabolite generation (J Clin Invest. 2018;128:3333-40). A summary is found here.
This position is ideal for someone strongly interested in rapid translation of basic mechanistic discoveries to the bedside as this is a principal goal of the Sharifi laboratory: we found our discovery of a gain-of-function in a steroid-synthesizing enzyme predicts poor outcomes after hormonal therapy (Lancet Oncol. 2016;17:1435-44; JAMA Oncol. 2018;4:558-62). We are evaluating this biomarker in an active clinical trial, pursuing similar mechanisms, and developing new treatments.
The position will provide unique, multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Details and the interest our research is generating are at: www.lerner.ccf.org/cancerbio/sharifi/
The ideal candidate has a Ph.D. in biochemistry, chemistry or molecular biology; appropriate expertise in discovery of molecular, biochemical or chemical mechanisms; and is highly driven. Outstanding verbal and communication skills are required. Send your CV and contact information for 3 references to:
Nima Sharifi, M.D.
Kendrick Family Chair for Prostate Cancer Research
Director, GU Malignancies Research Center
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