Postdoc position to study DNA repair and response to therapy in patient-derived organotypic models of ovarian cancer.

Postdoctoral position

Application deadline: 30 Nov 2023

Institute: IEO - European Institute of Oncology, Milano.
Country: Italy
More information: https://www.research.ieo.it/research-and-technology/principal-investigators/ugo-cavallaro/

A postdoctoral fellowship is available from January 2024 in the Unit of Gynecological Oncology Research, directed by Ugo Cavallaro, at the European Institute of Oncology, IFOM-IEO Campus, Milan, Italy, to study the molecular and functional impact of DNA repair variants on targeted and immune-based therapies of ovarian cancer. The postdoc will profit from unique experimental resources and leading expertise on ovarian cancer modeling (Nieddu et al, Cell Death Dis 2023, Lupia et al, Int J Cancer 2022, Giordano et al, J Exp Clin Cancer 2021, Lupia et al, Stem Cell Reports 2018; Francavilla et al, Cell Reports 2017; Zecchini et al, EMBO Mol Med 2011). Moreover, our close interaction with the Division of Gynecology grants the opportunity to investigate patient-specific experimental models of outstanding clinical relevance. Further info on research activities of the group is available at https://www.research.ieo.it/research-and-technology/principal-investigators/unit-of-gynecological-oncology-research/.

In particular, the postdoc will capitalize on new-generation organotypic models and cutting-edge genome editing techniques to determine the impact of nucleotide variants in disease-related genes on response to DNA damage response and anti-tumor immunity. The project will be developed in close collaborations with other groups in New York and Chicago, leading experts in the fields of genome stability and immuno-oncology, respectively, and will offer the opportunity to visit the partners’ laboratories in order to exchange knowledge and models.

We are looking for a highly motivated scientist willing to apply a wide range of cutting-edge cell and molecular biology techniques (primary cell cultures, organotypic models, CRISPR screening, immune-related assays, etc.), as well as mouse models of tumorigenesis, to define the impact of a series of newly identified mutations on the response of ovarian cancer to targeted therapies and immunotherapy

Job requirements:
· PhD in Molecular Biology, Cancer Biology or other related disciplines
· Solid expertise in cellular and molecular biology
· Strong motivation and research commitment
· Excellent analytical and organization skill
· Ability to work in team conjugated with independence
· Fluency in English

Previous experience with mouse models, genome-editing techniques and/or immune-oncology is a clear plus.

Competitive salaries will depend on the candidate’s track record and experience. According to current rules, foreign candidates and Italian candidates working abroad may be eligible for generous tax benefits upon relocation.
The position is for one year and is renewable.

Applicants should send their CV along with a brief motivation letter and with the name and contact details of two/three references to Ugo Cavallaro at ugo.cavallaro@ieo.it.

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