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Post-doctoral position, Cancer Cell Biology, Institut Curie, Paris, France

Postdoctoral position

No official deadline for applications

Project title: Lung-cancer-on-chip: immunocompetent tumor ecosystems reconstitution as a novel experimental paradigm for pre-clinical immunotherapy studies

A major challenge in cancer research is the complexity of the tumor microenvironment which includes the host immune cells. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices (integrating four cell populations: cancer, immune, endothelial and fibroblast) to reconstitute and visualize ex vivo human tumor ecosystems. These tumors-on-chip are powerful novel platforms to study ex vivo immunocompetent tumor microenvironments, to characterize ecosystem-level drug responses, and to dissect the roles of stromal components.

By combining advanced microfluidics and cell biology, we aim at developing a biomimetic lung-cancer-on-chip platform for pre-clinical studies, with a perfused vascular compartment, cancer-associated fibroblasts, and autologous immune cells. Immune Checkpoint Inhibitors (ICI) drugs led to a therapeutic revolution for lung cancer patients, however, only 20-30% of lung cancer patients are sensitive to ICI, and resistance mechanisms emerge. In the context of this lung-cancer-on-chip, we will evaluate the efficacy of anti-cancer ICI drugs and the influence of various controllable parameters, in order to better understand the mechanisms underlying immunotherapy efficacy and resistance.

We are seeking for a post-doc candidate with a background in Cell Biology. Some experience in Vascular Biology, Microfluidics (organ-on-chip), Immunology and/or Cell Image analysis will be a plus.

Net salary will be approximately 2300-2500 €/month, depending on experience, for 28 months.
The candidate will develop this project at Institut Curie, which is located in the heart of Paris, and will qualify for all social/health benefits of Curie employees.

Candidates should send application (CV, motivation letter, 2-3 recommendation contacts) to: maria-carla.parrini@curie.fr

Recent relevant publications

  1. Dissecting effects of anti-cancer drugs and of cancer-associated fibroblasts by on-chip reconstitution of immunocompetent tumor microenvironments
    Nguyen M, …, Parrini MC
    Cell Reports, accepted
  2. Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.
    Costa A,…, Mechta-Grigoriou F.
    Cancer Cell. 2018 Mar 12;33(3):463-479.e10.
  3. Transient microfluidic compartmentalization using actionable microfilaments for biochemical assays, cell culture and organs-on-chip.
    Yamada A, …, Descroix S.
    Lab Chip. 2016 Nov 29;16(24):4691-4701.

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