Listed times are in Central European Summer Time (CEST)

WELCOME TO DAY ONE

Session One Drivers of early tumorigenesis

Chair: Michaela Frye

Jane Visvader

"Using stem cell biology to decipher breast cancer"

Q&A 13:25 - 13:35

Pekka Katajisto

“Stem cell niche interactions in early tumorigenesis”

Q&A 13:55 - 14:05

Proffered Paper 1: William Hill Francis Crick Institute, London, UK

‘Lung Adenocarcinoma Promotion by Air Pollutants’

Q&A 14:15 - 14:20

Break

Session Two From tissue stemness to cancer

Chair: Meritxell Huch

Kamil Kranc

"The impact of RNA modifications on normal and malignant haematopoiesis”

Q&A 14:55 - 15:05

Proffered Paper 2: Lidia Fortuny University of Barcelona, Barcelona, Spain

‘Metabolic heterogeneity as a driver of stem cell fate and tumorigenesis in the intestine’

Q&A 15:15 - 15:20

Tuomas Tammela

“Aging-induced reprogramming of the cell of origin defines lung cancer evolution”

Q&A 15:40 - 15:50

POSTER SPOTLIGHTS

Chair: Ilaria Malanchi

Chiara Battistini, IEO, Milan, Italy; Mariana Bustmente Eduardo, Northwestern University, Chicago, USA; Ana Rita Silva, i3S, Porto, Portugal

Transition to Poster Discussion Session

POSTER DISCUSSION SESSION 1

Listed times are in Central European Summer Time (CEST)

POSTER DISCUSSION SESSION 2

Transition to Webinar

WELCOME TO DAY TWO

Session 3 Cancer plasticity

Chair: Mohamed Bentires-Alj

Richard White

“What determines oncogenic competence?”

Q&A 14:25 - 14:35

Proffered Paper 3: Panagiotis Karras VIB Center for Cancer Biology, Leuven, Belgium

‘Dissecting cell state diversity during melanoma growth and metastasis’

Q&A 14:45 - 14:50

Direna Alonso-Curbelo

"Epigenetic licensing of neoplastic plasticity in pancreatic cancer"

Q&A 15:10 - 15:20

Break

Session 4 Therapy opportunities

Chair: Tuomas Tammela

Maria Alcolea

"From development to homeostasis and back"

Q&A 15:55 - 16:05

Dana Ishay-Ronen

"Cancer cell plasticity as a window for trans-differentiation treatment"

Q&A 16:25 - 16:35

Proffered Paper 4: Giorgio Seano Institut Curie, Orsay, France

‘Glioblastoma vessel co-option and resistance to chemoradiation’

Q&A 16:45 - 16:50

DISCUSSION FORUM

Nature vs Nurture: how does phenotypic plasticity relate to mutational driven somatic evolution in cancer?

Chair: Ilaria Malanchi

Speakers: Tuomas Tammela, Richard White, Direna Alonso-Curbelo and Maria Alcolea

END OF DAY TWO SUMMARY