Listed times are in Central European Time (CET)

WELCOME TO DAY ONE

Chair: Jukka Westermarck

Stephin Vervoort Walter and Eliza Hall Institute of Medical Research, Australia

"The Rise of the Anti-Terminators: How CDK12/13 combat transcriptional terminators to keep RNA Polymerase II on course"

Q&A 13:25 - 13:35

Mutsuhiro Takekawa University of Tokyo, Japan

"Transcriptional regulation of immediate-early genes by a novel ERK substrate protein and its failure in cancer"

Q&A 13:55 - 14:05

Tim Lebedev Engelhardt Institute of Molecular Biology, Russia

Proffered Paper 1: "Pan-cancer profiling of ERK1/2 activity with single cell imaging predicts anticancer drug synergy with ERK inhibitors."

Q&A 14:15 - 14:20

Refreshment break

Chair: Chiara Ambrogio

Jukka Westermarck Turku Bioscience Centre, University of Turku, FInland

"DUSP6 inhibition overcomes Neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer"

Q&A 15:00 - 15:10

Mariangela Russo University of Turin, Italy

"Leveraging DNA Damage Response to prevent secondary resistance to MAPK pathway inhibition"

Q&A 15:30 - 15:40

Dan Lu Harvard Medical School, USA

Proffered Paper 2: "Integration of p53 dynamics and modifications regulate temporal therapeutic response"

Q&A 15:50 - 15:55

Refreshment break

Gad Getz Broad Institute, USA

"Finding mechanisms of resistance in cancer"

Q&A 16:35 - 16:45

POSTER SPOTLIGHTS

DAY 1 SUMMARY

Transition break

VIRTUAL POSTER DISCUSSION SESSION ONE

Listed times are in Central European Time (CET)

VIRTUAL POSTER DISCUSSION SESSION TWO

Transition break

WELCOME TO DAY TWO

Chair: Yaara Oren

Bernhard Küster Technical University of Munchen, Germany

"Decrypting drug actions and protein modifications by dose- and time-resolved proteomics"

Q&A 14:25 - 14:35

Jean-Emmanuel Sarry Toulouse Cancer Research Center, France

"Mitochondrial signaling circuits in response to therapy of acute myeloid leukemia."

Q&A 14:55 - 15:05

Alessandra Allotta Royal College of Surgeons in Ireland, Ireland

Proffered Paper 3: "Insights into the biological effect of targeting CDK12 in advanced ER+ breast cancer"

Q&A 15:15 - 15:20

Refreshment break

Chair: Jukka Westermarck

Nikhil Gupta Turku Bioscience Centre. Finland

Proffered Paper 4: "Species-specific differences in Malignant Transformation: Role of PP2A and its implications for cancer therapy"

Q&A 15:50 - 15:55

Yaara Oren Tel Aviv University, Israel

"Identifying the mechanisms underlying persistence potential and drug-induced cellular memory"

Q&A 16:15 - 16:25

Sydney Shaffer University of Pennsylvania, USA

"Tracking the origins of metaplasia and cancer"

Q&A 16:45 - 16:55

Refreshment break

Michelle Arkin University of California San Francisco, USA

"Modulating Cancer Networks with Molecular Glues"

Q&A 17:35 - 17:45

CONFERENCE SUMMARY

Our Scientific Programme Committee members, Jukka Westermarck, Chiara Ambrogio and Yaara Oren will join together to deliver their thoughts and a summary of the meeting.