Seed and Soil: Mechanisms of Metastasis
Berlin, Germany : 7 - 9 October 2019
Berlin, Germany : 7 - 9 October 2019
Registration
Tea/coffee available
Conference Welcome
Scientific Programme Committee
Session 1 - Metastasis Initiation
Chair: Janine Terra Erler
The EMBO Keynote Lecture
Cedric Blanpain ULB, Belgium
"Tumor transition states and metastasis"
Jonathan Sleeman University of Heidelberg, Germany
"Matrix-Assisted Autocrine Signaling"
Luigi Ombrato The Francis Crick Institute, UK
Proffered Paper 1: "A novel in vivo labelling system reveals tissue parenchyma stem cell features in the metastatic niche"
EXHIBITOR INTRODUCTIONS
60-second intro pitches by each company
COFFEE BREAK
Trade exhibition opens at 16:20
Rosandra Kaplan NCI/NIH, USA
"Stromal and Immune Cell Plasticity in the Pre Metastatic Niche and Metastatic Progression"
Christoph Klein University of Regensburg, Germany
"Mechanisms of early metastatic spread and colony formation: insights from the analysis of disseminated cancer cells"
Sarah Weischer Radboudumc, Netherlands
Proffered Paper 2: "An intravascular tumor niche identified by deep-tumor multiphoton endomicroscopy"
Jim Norman Beatson Institute, UK
"A role for integrin trafficking in metastatic niche priming"
POSTER SPOTLIGHTS
Three top-scoring abstracts presented in 3 minute 'flash talks'
WELCOME RECEPTION
with drinks and a hot buffet dinner
POSTER DISCUSSION SESSION 1
Conference dinner
Optional ticketed dinner beginning with a drinks reception in the Planck Lobby of Harnack House
POSTER VIEWING
Tea/coffee available
Sarah-Maria Fendt VIB-KU Leuven, Belgium
"The role of metabolism is metastasis formation"
Session 2 - Metastasis Maintenance & Formation
Chair: Andreas Trumpp
Eduard Batlle IRB Barcelona, Spain
"Immune evasion and metastasis in colorectal cancer"
Keynote Lecture
Caroline Dive CRUK Manchester Institute, UK
"New approaches to studying lung cancer metastasis using circulating tumour cells"
COFFEE BREAK
Anna Lorentzen Aarhus University, Denmark
Proffered Paper 3: "Single-cell polarity as a pro-metastatic feature of circulating tumour cells"
Julio Aguirre-Ghiso The Icahn School of Medicine at Mount Sinai, USA
"Dormant DCCs and adult stem cell niches: a homeostatic seed and soil partnership"
Gabriele Bergers VIB-KU Leuven Center for Cancer Biology, Belgium
"Creating an immunostimulating tumor microenvironment: From vessel pruning to vessel tuning"
POSTER SPOTLIGHTS
Three top-scoring abstracts presented in 3 minute 'flash talks'
INDUSTRY SYMPOSIUM - 10x Genomics
Hannes Arnold 10x Genomics
"Profiling the Tumor Microenvironment: Functional Characterization at Single Cell Resolution and Spatial Gene Expression"
LUNCH
POSTER DISCUSSION SESSION 2
Tea/coffee available
Session 3 - Targeting Metastasis I
Chair: Sarah-Maria Fendt
Andreas Trumpp DKFZ, Germany
"Exploring CDK4/6 inhibitor drug resistance at the single cell level in metastatic breast cancer CTCs"
Gopalakrishnan Ramakrishnan UIC, USA
Proffered Paper 4: "The AMP activated protein kinase promotes metastasis through the regulation of ROS production"
Veronique Orian-Rousseau KIT, Germany
"Dual function of CD44 in cancer cells and in the tumor stroma"
Discussion Forum
Chaired by Caroline Dive, the panel of invited speakers will tackle this important question.
“To EMT or not to EMT, or anything in between?”
POSTER VIEWING
Tea/coffee available
Meet the Expert talk
Andreas Trumpp DKFZ, Germany
Session 4 - Targeting Metastasis II
Chair: Jonathan Sleeman
Janine Erler University of Copenhagen, Denmark
"ECM remodelling during cancer progression"
Karen Vousden The Francis Crick Institute, UK
"A role for ROS in regulating metastasis"
COFFEE BREAK
Trade exhibition closes at 11:00
Emma Nolan The Francis Crick Institute, UK
Proffered Paper 5: "Lung exposure to ionizing radiation elicits neutrophil-mediated tissue perturbations and creates a pro-metastatic microenvironment"
Thordur Oskarsson DKFZ, Germany
"Regulation of the metastatic niche in breast cancer"
Keynote Lecture
Patricia Steeg NCI/NIH, USA
"The Blood-Tumor Barrier of Brain Metastases"
CLOSING SUMMARY & AWARDS CEREMONY
Scientific Programme Committee
BEUG FOUNDATION METASTASIS PRIZE
LUNCH & DEPART