Listed times are in Central European Time (CET)

Welcome to Day 1

Christoph Klein

Session 1 - Dormancy

Chair: Julio Aguirre-Ghiso

Laura Vera Ramirez GENYO-University of Granada, Spain

“Disseminated dormant breast cancer cells maintain redox homeostasis through organelle turnover and metabolic adaptation”

Q&A: 13:25 - 13:45

Julio Aguirre-Ghiso Albert Einstein College of Medicine, USA

"Single-cell analysis of early disseminated cancer cells identifies a tissue resident macrophage-driven mesenchymal-like dormancy program that suppresses metastasis"

Q&A: 14:05 - 14:25

15-minute break

Session 2 - Metabolism

Chair: Sarah-Maria Fendt

Sarah-Maria Fendt VIB-KU Leuven Center for Cancer Biology, Belgium

"Nutrient dependencies of metastasis formation"

Q&A: 15:00 - 15:20

Marco Montagner University of Padua, Italy

Proffered Paper 1: "EphB6 Regulates TFEB-Lysosomal Pathway and Survival of Disseminated Indolent Breast Cancer Cells"

Q&A: 15:30 - 15:40

Zeinab Homayed Institute of Functional Genomics (IGF), France

Proffered Paper 2: "Early dissemination highly enhances liver metastasis development in mouse models for intestinal tumorigenesis"

Q&A: 15:50 - 16:00

15-minute break

Srinivas Malladi UT Southwestern Medical Centre, USA

"Targetable vulnerabilities of latent breast cancer brain metastatic cells"

Q&A: 16:35 - 16:55

Poster Spotlights

3 top abstracts presented as 3-minute flash talks

End of Day 1 Webinar

Once the Webinar has ended we will take a 15-minute break before we begin our Virtual Poster Discussion Session 1

Virtual Poster Discussion Session 1

An informal and interactive 'virtual' opportunity for participants to browse the posters and make new connections. This 60-minute session will be delivered through the Zoom Meeting platform.

Listed times are in Central European Time (CET)

Virtual Poster Discussion Session 2

An informal and interactive 'virtual' opportunity for participants to browse the posters and make new connections. This 60-minute session will be delivered through the Zoom Meeting platform.

30-minute transition break

Welcome to Day 2

Session 3 - Cancer evolution, plasticity and progression

Chair: Christoph Klein

Christoph Klein University of Regensburg, Germany

"Cellular plasticity during metastatic colony formation in patients"

Q&A: 14:25 - 14:45

Adrià Cañellas IRB Barcelona, Spain

Proffered Paper 3: "Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells"

Q&A: 14:55 - 15:05

10-minute break

Harald Schuhwerk University of Erlangen–Nuremberg, Germany

Proffered Paper 4: "ZEB1 suspends anti-tumor immune defenses in colorectal cancer by tuning the functional diversity of cancer-associated fibroblasts (CAFs)"

Q&A: 15:25 - 15:35

Cathrin Brisken EPFL, Switzerland & The Institute of Cancer Research, UK

"Epithelial mesenchymal plasticity and control of ER+ breast cancer dormancy"

Q&A: 15:55 - 16:15

15-minute break

Session 4 - Immunology

Chair: Cyrus Ghajar

Ana Luisa Correia Champalimaud Foundation, Portugal

"Revisiting NK cell immunity to prevent metastasis"

Q&A: 16:50 - 17:10

Cyrus Ghajar Fred Hutchinson Cancer Research Center, USA

"Understanding and overcoming disseminated tumor cell immune evasion"

Q&A: 17:30 - 17:50

10-minute break

Discussion Forum

Chistoph Klein, Sarah-Maria Fendt, Julio Aguirre-Ghiso, Cyrus Ghajar

"How to translate emerging findings for the prevention of lethal metastatic disease"

End of Day 2 Summary