Q&A: 14:10 - 14:25

REGISTRATION

until 13:30

WELCOME LUNCH & TRADE EXHIBITION

CONFERENCE WELCOME

Scientific Programme Committee

SESSION 1: Cancer metabolism, autophagy and tumor microenvironment

Chair: Verena Jendrossek

The EMBO Keynote Lecture

Sharon Tooze The Francis Crick Institute, UK

"Molecular mechanisms of autophagosome formation"

Katja Simon Kennedy Institute of Rheumatology, UK

“Autophagy in cell fate decisions in the immune & hematopoietic system"

Q&A: 14:45 - 14:55

Monica Vara-Perez VIB – KULeuven, Belgium

Proffered Paper 1: "BNIP3 sustains HIF1α to promote melanoma growth and dissemination"

Q&A: 15:05 - 15:10

EXHIBITOR INTRODUCTIONS

60-second intro by each company

COFFEE BREAK & TRADE EXHIBITION

Patrizia Agostinis VIB – KULeuven, Belgium

"Autophagy in tumor angiogenesis"

Q&A: 16:10 - 16:20

Almut Schulze DKFZ, Germany

“Understanding the complex role of lipid metabolism in cancer”

Q&A: 16:40 - 16:50

Sarah-Maria Fendt VIB-KU Leuven, Belgium

“The role of metabolism in metastasis formation”

Q&A: 17:10 - 17:20

POSTER SPOTLIGHTS

3 top-scoring abstracts (posters 1-3) presented in 3 minute 'flash talks'

NETWORKING RECEPTION

An opportunity to make new connections over a drink and some light food

POSTER DISCUSSION SESSION 1

until 19:30

Posters 1-30 will be presented

POSTER VIEWING & TRADE EXHIBITION

until 09:00

Coffee / tea available

INDUSTRY SPOTLIGHT - VectorBuilder

Matthew Wheeler

"VectorBuilder - Advances in vector construction and virus packaging"

SESSION 2: Cell death mechanisms

Chair: Peter de Keizer

Keynote Lecture

René Bernards NKI, Netherlands

“Exploiting senescence for the treatment of cancer”

Q&A: 09:30 - 09:45

Nataly Kravchenko-Balasha The Hebrew University of Jerusalem, Israel

Proffered Paper 2: "Deciphering the intra-tumor and inter-patient signaling heterogeneity in cancer for the rational design of patient specific drug cocktails"

Q&A: 09:55 - 10:00

David Wallach Weizmann Institute of Science, Israel

“Novel insights into the functional roles of the signaling pathway for necroptotic death"

Q&A: 10:20 - 10:30

COFFEE BREAK & TRADE EXHIBITION

Marion MacFarlane MRC Toxicology Unit, UK

"Uncovering the Therapeutic Potential of BH3-mimetics in Patient-relevant Pre-clinical Models of Mesothelioma''

Q&A: 11:25 - 11:35

Samuel Sidi Icahn School of Medicine at Mount Sinai, USA

Proffered Paper 3: "FANCI Functions as a Repair/Apoptosis Switch in Response to DNA Crosslinks"

Q&A: 11:45 - 11:50

Dagmar Kulms TU Dresden, Germany

“Caspase-8 promotes progression of p53-proficient tumors"

Q&A: 12:10 - 12:20

POSTER SPOTLIGHTS

3 top-scoring abstracts (posters 31-33) presented in 3 minute 'flash talks'

LUNCH & TRADE EXHIBITION

POSTER DISCUSSION SESSION 2

Posters 31-59 will be presented

SESSION 3: Senescence, cancer and therapeutic targeting

Chair: Patrizia Agostinis

Manuel Serrano ICREA Professor, IRB Barcelona, Spain

“Cellular senescence as a driver of multiple human diseases"

Q&A: 14:50 - 15:00

Marco Demaria ERIBA/UMCG, The Netherlands

"Modulating senescence-associated phenotypes to prevent side effects of cancer therapy"

Q&A: 15:20 - 15:30

Olivier E. Pardo Imperial College, UK

Proffered Paper 4: "Targeting the S6 kinase, RSK4, prevents chemoresistance and metastasis in lung cancer"

Q&A: 15:40 - 15:45

COFFEE BREAK & TRADE EXHIBITION

Laura Conti MBC, University of Torino, Italy

Proffered Paper 5: "The immunotargeting of the xCT cystine/glutamate antiporter targets cancer stem cells and potentiates the efficacy of Her2-targeted immunotherapies in breast cancer"

Q&A: 16:25 - 16:30

Peter de Keizer UMC Utrecht, The Netherlands

"Targeting Heterogeneity in Senescence against Aging and Cancer"

Q&A: 16:50 - 17:00

Daniel Murphy CRUK Beatson Institute, UK

"Partners in crime: MYC, RAS and cell-extrinsic mechanisms of oncogenic cooperation"

Q&A: 17:20 - 17:30

DISCUSSION FORUM

until 18:30

Chaired by Patrizia Agostinis, the panel of invited speakers will tackle this important question.

“Novel frontiers in regulated cell death and senescence: what is the desirable type of cell inactivation in cancer therapy?”

Conference Dinner

Optional ticketed dinner at Taverna Valtellinese

POSTER VIEWING & TRADE EXHIBITION

until 09:00

Coffee / tea available

INDUSTRY SPOTLIGHT - Tecan

Stefan Haberstock

"Optimization of drug titration in cell based assays"

MEET THE EXPERTS TALK

Silvia Formenti & Verena Jendrossek

An interactive session with a focus on women in science where our two experts will share from their personal and professional perspectives on the path to scientific leadership.

SESSION 4: Harnessing cell death and cancer vulnerabilities for cancer therapy

Chair: Marion MacFarlane

Clemens Schmitt MDC Berlin, Germany

"Post-senescence: a matter of life and death"

Q&A: 10:05 - 10:15

Verena Jendrossek Universität Duisburg-Essen, Germany

"Novel opportunities for a biologic optimization of radiotherapy"

Q&A: 10:35 - 10:45

COFFEE BREAK & TRADE EXHIBITION

Serk In Park Korea University College of Medicine, South Korea

Proffered Paper 6: "Mobilization of Monocytic Myeloid-Derived Suppressor Cells (MDSC) Is Regulated by Osteoblast Activation by PTH1R"

Q&A: 11:25 - 11:30

Brent Stockwell Columbia University, USA

“Ferroptosis: mechanisms and therapeutic potential"

Q&A: 11:50 - 12:00

Closing Keynote

Silvia C. Formenti Weill Cornell Medicine, USA

“Radiotherapy to convert the tumor into an in situ vaccine"

Q&A: 12:30 - 12:45

Conference Summary

Scientific Programme Committee

LUNCH & DEPART