A Matter of Life or Death: From Basic Cell Death Mechanisms to Novel Cancer Treatments

Amsterdam, Netherlands : 1 - 3 February 2018

Scientific Programme

Thursday 1st February 2018

11:00

Registration

Rode Hoed foyer

until 13:00

12:00

Welcome Lunch & Opening of the Trade Exhibition

Including tea/coffee

13:00

Conference Welcome

Oosterhuiszaal

Scientific Programme Committee

Session 1: MECHANISTIC INSIGHT IN the regulation of AUTOPHAGY AND the role of SENESCENCE as tumour suppressor

Chairs: Simone Fulda & Guillermo Velasco

13:05

Opening Keynote Lecture

Kevin Ryan Beatson Institute, UK

"Autophagy and cancer: issues we need to digest"

13:50

Tor Erik Rusten Oslo University Hospital, Norway

"Non-autonomous tumor growth support by autophagy"

14:20

Oriol de Barrios IDIBAPS, Spain

Proffered Paper 1: "The EMT-factor ZEB1 promotes tumor progression through inhibition of cell senescence"

14:35

EXHIBITOR INTRODUCTIONS

14:45

COFFEE BREAK & TRADE EXHIBITION

Oosterhuiszaal & Foyer

Session 2: REGULATION OF CLASSICAL AND NON-CLASSICAL MODES OF APOPTOSIS

Chairs: Eugenia Piddini & Kevin Ryan

15:15

EMBO Young Investigator Lecture

Ana J. García-Sáez Universität Tübingen, Germany

"Bax and Bak at the single molecule level: telling the twins apart"

15:45

Jan Paul Medema AMC, Netherlands

"Colorectal cancer, four subtypes with distinct biology"

16:15

POSTER DEFENCE SESSION 1

Lower Balcony

17:45

NETWORKING RECEPTION & TRADE EXHIBITION

Oosterhuiszaal & Foyer

With drinks & hot buffet dinner

19:00

Evening Keynote Lecture

Scott Dixon Stanford University, USA

"The regulation of ferroptosis in cancer cells"

Friday 2nd February 2018

08:30

POSTER VIEWING & TRADE EXHIBITION

Oosterhuiszaal & Lower Balcony

Coffee available to purchase

Session 3: Role of cell survival and death signaling in cancer susceptibility, tumour growth and therapy response

Chairs: Jan Paul Medema & John Silke

09:00

Eugenia Piddini University of Bristol, UK

"The role of cell competition in tumour promotion"

09:30

Peter de Keizer UMC Utrecht, Netherlands

"Targeted apoptosis of senescent cells against aging and cancer"

10:00

Yaron Fuchs Technion, Israel

Proffered Paper 2: "Caspase-3 Regulates YAP-dependent Cell Proliferation and Organ Size"

10:15

Michael Hahne CNRS / IGMM, France

Proffered Paper 3: "Primary cilia modulate susceptibility to colon carcinogenesis"

10:30

COFFEE BREAK & TRADE EXHIBITION

Oosterhuiszaal & Foyer

11:00

Stephen Tait Beatson Institute, UK

"Mitochondrial apoptosis and cancer: from phantom menace to a force awakens"

11:30

Giorgio Stassi Palermo University, Italy

"MAPK, PI3K and HER2 inhibition induces synthetic lethality in colorectal cancer stem cells regardless their mutational status"

12:00

BUFFET LUNCH & TRADE EXHIBITION

Oosterhuiszaal & Foyer

Session 4: Impact of cell death on immune responses to cancer and cancer therapies

Chairs: Ana J. García-Sáez & Manolis Pasparakis

13:00

Verena Jendrossek Universität Duisburg-Essen, Germany

"Normal tissue response to ionizing radiation and therapeutic targeting"

13:30

Sandra Demaria Weill Cornell Medical College, USA

"Mechanisms regulating the immunogenicity of radiation-induced cancer cell death"

14:00

Inge Verbrugge NKI, Netherlands

Proffered Paper 4: "Chemo-Radio-Immunotherapy: Cisplatin improves abscopal effects following radiotherapy and a-CD137/a-PD1 mAbs"

14:15

Jolien Bridelance VIB-UGent, Belgium

Proffered Paper 5: "Identification of molecular mechanisms essential for necroptosis execution by using a genome-wide CRISPR-Cas knockout screening"

14:30

Karin de Visser NKI, Netherlands

"The immune system: a double-edged sword in metastatic breast cancer"

15:00

POSTER DEFENCE SESSION 2

Lower Balcony

Coffee served

16:30

Round Table Discussions

Oosterhuiszaal

until 17.30

This session enables participants and speakers to converse informally in smaller groups. Participants are free to ask any questions they like and to move freely between the groups of different speakers.

19:30

CONFERENCE DINNER

Restaurant-Café In De Waag

Pre-booked optional extra

Saturday 3rd February 2018

08:30

POSTER VIEWING & TRADE EXHIBITION

Oosterhuiszaal & Lower Balcony

Coffee available to purchase

Session 5: Cell death regulation in cancer and therapeutic targeting

Chairs: Verena Jendrossek & Stephen Tait

09:00

Andreas Villunger Medical University of Innsbruck, Austria

"The PIDDosome – a signalling platform controlling p53 activation"

09:30

Simone Fulda UCT Frankfurt, Germany

"Novel opportunities to target cell death pathways for cancer therapy"

10:00

Prashanthi Ramesh AMC, Netherlands

Proffered Paper 6: "BCL-xL specific stem cell resistance is maintained through colon cancer transformation and allows identification of optimal combination strategies"

10:15

Silvia Vega-Rubin-de-Celis DKFZ, Germany

Proffered Paper 7: "Inhibition of HER2 tumorigenesis by Beclin 1 and an autophagy-inducing peptide"

10:30

COFFEE BREAK & TRADE EXHIBITION

Oosterhuiszaal & Foyer

11:00

John Silke Walter and Eliza Hall Institute, Australia

"Pump it Up - Will Smac-mimetics make it into the clinic? If so how and when?"

11:30

Guillermo Velasco Complutense University, Spain

"Molecular mechanisms involved in the stimulation of autophagy-mediated cancer cell death"

12:00

Evangelos Kondylis University of Cologne, Germany

"IKK/NF-kB and RIPK1 signalling in cell death and inflammation"

12:40

Closing summary

Scientific Programme Committee

Poster Prizes and Meeting Bursaries will be presented by Verena Jendrossek

13:00

LUNCH AND DEPART

Rode Hoed foyer

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