Listed times are in Central European Summer Time (CEST)

REGISTRATION & WELCOME LUNCH (lunch from 12:00)

Light refreshments will be served.

CONFERENCE WELCOME

Session 1: Cell-based Therapies

Chair: Valerie Weaver

Opening Keynote Lecture

Michael Milone Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

'Navigating Beyond the Cancer Therapy Horizon with Engineered T cells'

Q&A 13:35 - 13:50

Emmanuel Donnadieu Institut Cochin, Paris, France

'Predicting the Safety and Efficacy of Engineered T Cells Using an Ex Vivo Human Model'

Q&A 14:10 - 14:20

Joash Joy Barts Cancer Institute, Queen Mary University of London, UK

Proffered Paper 1: ‘Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR T cell activity’

Q&A 14:30 - 14:35

EXHIBITOR INTRODUCTIONS

COFFEE BREAK, EXHIBITION & SOLO TRAVELLER MEET-UP

Peter Friedl Radboud UMC, Nijmegen, Netherlands

'Life or death: monitoring the first days of metastatic organ colonization'

Q&A 15:45 - 15:55

Matt Paszek Smith School of Chemical and Biomolecular Engineering, Cornell University, New York, USA

'The sweet forces in control of 3D cellular morphology and function'

Q&A 16:15 - 16:25

POSTER SPOTLIGHTS

INDUSTRY SYMPOSIUM - InVivo BioTech Services

Tim Welsink InVivo BioTech Services

'Discover novel opportunities in antibody discovery, cell line development and functional single-cell analysis with Beacon® optofluidic technology'

Q&A: 16:55-17:05

NETWORKING QUIZ

WELCOME RECEPTION

POSTER DISCUSSION SESSION 1

Led by members of the Scientific Programme Committee

Listed times are in Central European Summer Time (CEST)

EARLY POSTER VIEWING WITH COFFEE

INDUSTRY SPOTLIGHT - Tecan

Roman Petrovsky Tecan

'Label-free spheroids and organoids analysis for assays development'

Session 2: Mechanobiology

Chair: Emmanuel Donnadieu

THE EMBO KEYNOTE LECTURE

Johanna Ivaska University of Turku, Turku, Finland

'3D matrix guided cues in cancer progression'

Q&A 09:20 - 09:30

Maria Benito Jardon The Francis Crick Institute, UK

Proffered Paper 2: ‘Melanoma cells orchestrate the composition of the tumour stroma via MRT-SRF signaling’

Q&A 09:40 - 09:45

Sara Wickstrom Max Planck Institute for Molecular Biomedicine, Munster, Germany

'Phenotype and cell state dynamics in cancer'

Q&A 10:05 - 10:15

Thomas H. Barker University of Virginia, Charlottesville, USA

'Mechanochemical dynamics of the provisional matrix critically instruct cell behaviors'

Q&A 10:35 - 10:45

COFFEE BREAK & EXHIBITION

Samantha Stehbens Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia

'The Mechanobiology of Melanoma: Understanding How Tumour Cells Survive Metastasis'

Q&A 11:35 - 11:45

Michelle Baird National Institutes of Health - NHLBI, USA

Proffered Paper 3: 'Lamin B Receptor Upregulation in Melanoma Causes Cholesterol-Mediated Nuclear Envelope Fragility During Metastasis'

Q&A 11:55 - 12:00

POSTER SPOTLIGHTS

INDUSTRY SYMPOSIUM - PromoCell

Janina Moros PromoCell

'Goodbye Clumps, Hello Tumorspheres!'

Q&A: 12:30-12:40

LUNCH

Light refreshments will be served.

POSTER DISCUSSION SESSION 2

Led by members of the Scientific Programme Committee

Session 3: Plasticity

Chair: Henriette Lanz

G V Shivashankar ETH Zurich, Zurich, Switzerland

'Mechano-genomics of tumor microenvironment and early diagnostics'

Q&A 15:30 - 15:40

Anna Mukha Radboud University Medical Center, Netherlands

Proffered Paper 4: 'Mechanical challenges define the efficiency of the early organ colonization by tumor cells'

Q&A 15:50 - 15:55

Bethany Bareham King's College London, UK

Proffered Paper 5: 'Extracellular biomechanics and Immune Modulation in Oral Squamous Cell Carcinoma Cells'

16:05 - 16:10

Kevin Myant University of Edinburgh, Edinburgh, UK

'Loss of colonic lineage fidelity permits induction of squamous-like plasticity and metastasis in colorectal cancer'

Q&A 16:30 - 16:40

COFFEE BREAK & EXHIBITION

Viola Vogel ETH Zurich, Zurich, Switzerland

'Mechanoregulation of the reciprocal ECM-cell crosstalk: does the tension of individual ECM fibers matter?'

Q&A 17:30 - 17:40

Chris Tape UCL Cancer Institute, London, UK

'Single-cell Phenoscaping of Tumour Microenvironment Organoids'

Q&A 18:00 - 18:10

CONFERENCE DINNER (Optional ticketed event)

Listed times are in Central European Summer Time (CEST)

EARLY POSTER VIEWING WITH COFFEE

INDUSTRY SPOTLIGHT - Greiner Bio-One

Jennifer Bischoff Greiner Bio-One

'Magnetic 3D Cell Culture – A innovative tool to simplify 3D Cell Culture'

Session 4: Modelling the Tumour Microenvironment

Chair: Viola Vogel

Henriette Lanz MIMETAS, Oegstgeest, Netherlands

'Influencing drug responses through in vitro tumour microenvironment characteristics: Development of organotypic patient-derived ovarian cancer models for therapy testing'

Q&A 09:20 - 09:30

Val Weaver UCSF, San Francisco, USA

'Leveraging 3D spheroids to clarify links between ECM stiffness and inflammation-dependent DNA damage and protumor mutations'

Q&A 09:50 - 10:00

Oihane Mitxelena-Iribarren Biogipuzkoa HRI, Spain

Proffered Paper 6: '3D bone organotypic models of dormant breast cancer metastasis to study cell-extracellular matrix interactions as a strategy for new therapies'

Q&A 10:10 - 10:15

COFFEE BREAK & EXHIBITION

David Bryant CRUK Beatson Institute, Glasgow, UK

'Examining the contribution of PTEN to colorectal cancer using in vitro-to-in vivo transplantation and CRISPR-mediated knockout.'

Q&A 11:05 - 11:15

Closing Keynote Lecture

Frances Balkwill CRUK, City of London Centre, UK

'3D multicellular models of ovarian cancer'

Q&A 11:40 - 11:55

SUMMARY & AWARDS