Listed times are in Central European Summer Time (CEST)

REGISTRATION & WELCOME LUNCH

CONFERENCE WELCOME

Session 1

Chair: Valerie Weaver

Andrew Ewald The Johns Hopkins University, USA

"Cell state and intercellular interactions coordinately regulate cancer invasion and metastasis"

Q&A: 13:30-13:40

Laura Machesky (Virtual Presentation) University of Cambridge, UK

"How cancer cells use mechanical cues to decide when to eat and when to walk"

Q&A: 14:00 - 14:10

Clemence Nguyen Vigouroux Gustave Roussy Institute, France

Proffered Paper 1: "Cancer cell collectives can alternate between migration strategies"

Q&A: 14:20 - 14:25

EXHIBITOR INTRODUCTIONS

COFFEE BREAK & EXHIBITION

Henriëtte Lanz MIMETAS, Netherlands

"Modelling the tumor microenvironment in order to place compounds and targets in the patient context"

Q&A: 15:25 - 15:35

KEYNOTE LECTURE

Erik Sahai Crick Institute, UK

"Unpicking How the Tumor Microenvironment Sculpts Cancer Invasion and Therapy Failure"

Q&A: 16:05 - 16:20

Poster Spotlights

3 top abstracts presented as 3-minute flash talks

SPEED NETWORKING RECEPTION

Invited speakers and the conference organizers will each host a table of participants, covering different topics for discussion.

Welcome Reception

Drinks reception with buffet served from 17:30

POSTER DISCUSSION SESSION 1

Listed times are in Central European Summer Time (CEST)

Poster viewing

Posters may be freely viewed. Tea/coffee/biscuits will be served.

Session 2

Chair: Emmanuel Donnadieu

INDUSTRY SPOTLIGHT - GREINER BIO-ONE

Torsten Binder Product Manager: 3D Cell Culture, Greiner Bio-One

'Tools to Simplify 3D Cell Culture'

Peter Friedl Radboud UMC, Netherlands

"Energy crisis and cell migration – how to get out of trouble"

Q&A: 09:20 - 09:30

Floriana Cremasco Roche Glycart AG, Switzerland

Proffered Paper 2: "Human 3D in vitro models for the assessment of Cancer Immunotherapy Mode of Action"

Q&A: 09:40 - 09:45

Daniela Thommen Netherlands Cancer Institute, Netherlands

‘Dissecting and modulating anti-tumor immunity in human cancers using ex vivo avatars’

Q&A: 10:05 - 10:15

Paul Timpson Garvan Institute of Medical Research, Australia

"Intravital imaging and insights into stromal co- targeting in pancreatic cancer"

Q&A: 10:35 - 10:45

COFFEE BREAK & EXHIBITION

Session 3

Chair: Peter Friedl

Silvia Scaglione React4Life, Italy

"A organ on chip-based approach for 3D cancer tissue culture towards a better understanding of human cancer progression and more predictive drug testing"

Q&A: 11:35 - 11:45

Claudia Beaurivage HUB Organoids, Netherlands

Proffered Paper 3: "Autologous organoids and T cell co-cultures as a powerful personalized platform for immunotherapy development"

Q&A: 11:55 - 12:00

Poster Spotlights

3 top abstracts presented as 3-minute flash talks

Christine Moussion Genentech, USA

"In situ tumour arrays reveal early environmental control of cancer immunity"

Q&A: 12:30-12:40

LUNCH & EXHIBITION

POSTER DISCUSSION SESSION 2

Session 4

Chair: Andrew Ewald

THE EMBO KEYNOTE LECTURE

Matthias Lütolf EPFL, Switzerland

"Engineering next-generation tumoroids"

Q&A: 15:20 - 15:35

Britta Trappmann TU Dortmund University, Germany

"Biomimetic models of the tumor-vascular niche"

Q&A: 15:55 - 16:05

Agathe Bessot Translational Research Institute, Australia

Proffered Paper 4: "Delineating the role of bone marrow adipocytes in advanced prostate cancer and therapy response using ECM-derived 3D hydrogels as in vitro and humanised in vivo platforms"

Q&A: 16:15 - 16:20

COFFEE BREAK & EXHIBITION

Valerie Weaver UCSF, USA

"Exploiting patient-derived organoids for drug discovery to overcome therapy resistance and tumor metastasis"

Q&A: 17:05 - 17:15

Nicolas Pasquier Turku Bioscience, Finland

Proffered Paper 5: "Focal adhesion signaling pathway controls apicobasal polarity of colorectal carcinoma metastases"

Q&A: 17:25 - 17:30

Meet the Expert

Andrew Ewald The Johns Hopkins University, USA

Prof Andrew Ewald will host an informal session where he will share his own personal and professional experiences of his path to scientific leadership.

Conference Dinner

The evening will begin with a Drinks Reception in the Planck Lobby of Harnack House at 19:15. The three-course served dinner will take place downstairs in the atmospheric restaurant from 19:30. Optional ticketed event.

Listed times are in Central European Summer Time (CEST)

Poster viewing

Posters may be freely viewed. Tea/coffee/biscuits will be served.

Session 5

Chair: Henriëtte Lanz

INDUSTRY SPOTLIGHT - TECAN

Dr Nicola Vettore Tecan

'Scaling 3D cell experiments with full automation workflows and AI-based analysis'

Emmanuel Donnadieu Institut Cochin, France

"Predicting safety and efficacy of engineered T cells using an ex vivo human model "

Q&A: 09:20 - 09:30

Jacky Goetz INSERM, France

"Intravascular forces shape tumor metastasis"

Q&A: 09:50 - 10:00

Brooke Pereira Garvan Institute of Medical Research, Australia

Proffered Paper 6: "Temporal quantitative proteomics and advanced microscopy to resolve matrisomal drivers of pancreatic cancer"

Q&A: 10:10 - 10:15

COFFEE BREAK & EXHIBITION

Luca Tiberi CIBIO - University of Trento, Italy

"Modeling brain tumor with human organoids"

Q&A: 11:05 - 11:15

CLOSING KEYNOTE LECTURE

Anne Rios Princess Máxima Center for Pediatric Oncology, Netherlands

"Organoid cellular cancer immunity models in motion"

Q&A: 11:45 - 12:00

SUMMARY & AWARDS

Depart