Registration

Tea/coffee available

Conference Welcome

Scientific Programme Committee

Opening Keynote Lecture

Dave Mooney Harvard University, USA

"Cells and viscoelasticity"

ICEBREAKER INTRODUCTIONS

An opportunity to make new connections over a drink.

WELCOME BUFFET & TRADE EXHIBITION

Meitner Hall & Goethe Hall

POSTER VIEWING & TRADE

Tea/coffee available

Session 1: 3D Models and drug development

Chair: Ellen Van Obberghen-Schilling

Neil Carragher University of Edinburgh, UK

"Advancing phenotypic drug discovery strategies through new cell-based assay technologies"

Henriette Lanz Mimetas, Netherlands

"Modelling the tumor microenvironment on-a-chip"

Georgios Giamas University of Sussex, UK

Proffered Paper 1: "3D co-culture invasion screening identifies fibroblast-expressed PIK3Cδ as a novel therapeutic target for TNBC"

EXHIBITOR INTRODUCTIONS

Short intro pitches by each company

COFFEE BREAK & TRADE

Kendelle Murphy Garvan Institute, Australia

Proffered Paper 2: "Personalised medicine approach in pancreatic cancer reveals fine-tuned stromal versus epithelial FAK manipulation to improve systematic response to Gemcitabine and Abraxane"

Hugo Snippert UMC Utrecht, Netherlands

"Real-time quantification of cellular drug response in patient-derived tumor organoids reveals heterogeneity in space and time"

POSTER SPOTLIGHTS

Abstracts 1-3 will be presented in short ‘flash talks’ of 3 minutes each.

INDUSTRY SYMPOSIUM - Greiner Bio-One

Glauco R. Souza Greiner Bio-One

"Magnetic 3D Cell Culture, 3D Cell Culture made as simple as 2D"

BUFFET LUNCH & TRADE

POSTER DISCUSSION SESSION 1

Posters 1-55 will be presented. Tea/coffee available.

Session 2: Cell Adhesion & Mechanobiology

Chair: Cathrin Brisken

Valerie Weaver UCSF, USA

"Deconstructing the third dimension"

Sara Wickström University of Helsinki, Finland

"Regulation of stem cell fate by niche-derived signals and forces"

Jessica Morgner NKI, Netherlands

Proffered Paper 3: "Lamb1Dendra2 – A new mouse model to study basement membrane dynamics in vivo"

Viola Vogel ETH Zürich, Switzerland

"Unraveling the mechanobiology of extracellular matrix and of macrophages"

Industry Spotlight - Quantum Design

Sumeer Dhar Screen GP Europe

"Novel Optical Coherence Tomography (OCT) technology for non-invasive 3D ex vivo imaging"

TECHNOLOGIES FORUM

Sign-up required. Invited speakers will host tables, each covering a different topic.

POSTER VIEWING & TRADE

Tea/coffee available

Meet the Expert talk

Neil Carragher University of Edinburgh, UK

An interactive session where our expert will share from their personal and professional perspectives on oscillating between academia and industry.

Session 3: tumour progression and mechanisms of invasion

Chair: Valerie Weaver

Peter Friedl Radboud UMC, Netherlands

"3D models to understand tissue remodeling and anti-cancer therapy in bone"

Cathrin Brisken EPFL, Switzerland

"Hormones and breast cancer: how models matter"

COFFEE BREAK & TRADE

Olivier De Wever Ghent University, Belgium

Proffered Paper 4: "Tumor engineered scaffolds to model peritoneal metastasis of serous ovarian carcinoma"

Tariq Haddad Radboud UMC, Netherlands

Proffered Paper 5: "A Colorectal Carcinoma in 3D: Merging Knife-Edge Scanning Microscopy and Deep Learning"

Ellen Van Obberghen-Schilling Institut de Biologie Valrose, France

"Shaping tumors and their microenvironment"

POSTER SPOTLIGHTS

Abstracts 56-58 will be presented in short ‘flash talks’ of 3 minutes each.

INDUSTRY SYMPOSIUM - Nexcelom

Gillian Farnie NDORMS, UK

"Breast Cancer Stem Cells – utilising in vitro assays to explore targets of tumour initiating cells"

BUFFET LUNCH & TRADE

POSTER DISCUSSION SESSION 2

Posters 56-111 will be presented. Tea/coffee available.

Session 4: regulating and remodeling the immune microenvironment

Chair: Peter Friedl

Keynote Lecture

Melody Swartz The University of Chicago, USA

"Modeling the tumor-immune microenvironment in vitro"

Eduard Batlle IRB Barcelona, Spain

"Immune evasion and metastasis in colorectal cancer"

COFFEE BREAK & TRADE

Mikala Egeblad Cold Spring Harbor Laboratory, USA

"Control of metastatic seeding and colonization by the microenvironment"

CONFERENCE DEBATE

Sara Wickström (for) and Senthil Muthuswamy (against)

"Smart 2D will be the new 3D" Invited speakers will discuss one of the key topics of the field. Participants will have a chance to vote on the debate, and to contribute to the conversation.

Free Time

Conference Dinner ticket holders not staying at Harnack House are welcome to relax in the Planck Lobby. Drinks may be purchased from Reception

CONFERENCE DINNER

Optional ticketed dinner

POSTER VIEWING & TRADE

Tea/coffee available

Session 5: multiplex imaging of cells

Chair: Neil Carragher

Emmanuel Donnadieu Institut Cochin, France

"Dynamic imaging of T cell antitumoral activities in human tumor biopsies"

Christian Conrad Berlin Institute of Health, Germany

"Spheroid imaging and sequencing"

INDUSTRY SYMPOSIUM - 10x Genomics

Marlon Stoeckius 10x Genomics

"A Multidimensional View of Biology using 10x Visium Spatial Gene Expression Solution"

COFFEE BREAK & TRADE CLOSES

Maria Alieva Prinses Maxima Centrum, Netherlands

Proffered Paper 6: "3D imaging and multivariate dynamics analysis reveal behavioral signatures that enable engineered T cells to target breast cancer organoids"

David Bryant Beatson Institute, UK

"Finding the order in chaos: understanding the heterogeneity of tumour cell invasion mechanisms"

Closing Keynote Lecture

Senthil Muthuswamy Harvard Medical School, USA

"From a road less traveled to a worn path: 3D culture and organoids for cancer biology and therapeutics"

Summary & Awards

LUNCH & DEPART