Listed times are in Central European Time (CET)

WELCOME TO DAY ONE

Kristian Helin and Ho Man Chan

TARGETING EPIGENETICS IN CANCER: SESSION 1

Chair: Mark Dawson

Ricky Johnstone Peter MacCallum Cancer Centre, Victoria, Australia

'Targeting transcriptional CDKs in cancer'

Q&A 13:30 - 13:45

Celine Vallot Institut Curie, Paris, France

'Epigenetic targeting of chemoresistance in cancer'

Q&A 14:05 - 14:20

Refreshment Break

Chair: Ho Man Chan

Eytan Stein MSKCC, New York, USA

'Novel epigenetic therapies for acute myeloid leukemia'

Q&A 14:55 - 15:10

Naiara Perurena Aizcorbe Brigham and Women's Hospital, Boston, USA

Proffered Paper 2: 'EZH2 Inhibitors Create a Dependency on YAP for Survival in HER2+ Breast Cancers'

Q&A 15:20 - 15:30

Refreshment break

Kathrin Bernt Children's Hospital of Philadelphia, Philadelphia, USA

'Intrinsically disordered domains and transcription control in cancer'

Chair: Jingwen Zhang

Q&A 16:10 - 16:25

POSTER SPOTLIGHTS

Chair: Jingwen Zhang

Daniel Angelov, Trinity College Dublin, Dublin, Ireland; Buse Cevatemre, Koç University, Istanbul, Turkey; María Rodrigo-Faus, Universidad Complutense de Madrid, Madrid, Spain

END OF DAY 1 WEBINAR

VIRTUAL POSTER DISCUSSION SESSION 1

Listed times are in Central European Time (CET)

VIRTUAL POSTER DISCUSSION SESSION 2

WELCOME TO DAY TWO

Kristian Helin and Ho Man Chan

TARGETING EPIGENETICS IN CANCER: SESSION 2

Chair: Mark Dawson

Oliver Raush Storm Therapeutics Ltd, Cambridge, UK

'Small molecule inhibition of the RNA methyltransferase METTL3 activates anti-tumour immune responses'

Q&A 14:25 - 14:40

Cintia Checa Rodriguez Institute of biomedicine of Sevilla (IBIS), Sevilla, Spain

Proffered Paper 3: 'RNAPII-facilitated repair of ribosomal DNA breaks in nucleolar caps guards against genomic instability'

Q&A 14:50 - 15:00

Refreshment Break

Chair: Jingwen Zhang

Leslie Duplaquet Dana Farber Cancer Institute, Boston, USA

Proffered Paper 4: 'KDM6A epigenetically regulates subtype plasticity in small cell lung cancer'

Q&A 15:25 - 15:35

Cigall Kadoch Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

'Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer'

Q&A 15:55 - 16:10

Refreshment Break

Chair: Cigall Kadoch

Ernesto Guccione EG Lab, Mount Sinai, New York, USA

'Precision medicine in solid tumors'

Q&A 16:45 - 17:00

Sangeeta Goswami MD Anderson Cancer Center, Houston, USA

'Targeting Epigenetic Pathways to Improve Response to Immune Checkpoint Therapy'

Q&A 17:20 - 17:35

DISCUSSION SESSION

'How to use Epigenetic Therapies in Cancer' and 'What epigenomic features need to be routinely measured in clinical protocol? Has this been done already? If not, why not?'

This will be an open forum with SPC members and speakers, Kristian, Ho Man, Eytan, Sangeeta and Celine

SUMMARY AND CLOSE

Kristian Helin and Ho Man Chan