Listed times are in Central European Time (CET)

WELCOME TO DAY ONE

Session 1: PROTACs and molecular glues – clinical stage

Chair: Paola Martinelli

Agnieszka Konopacka ICR, UK

'Engineering Proximity, Rewiring Biology, Transforming Cancer'

Q&A 12:25-12:35

Gwenn Hansen Nurix Therapeutics, USA

Q&A 12:55-13:05

Proffered Paper 1

Q&A 13:15-13:20

Proffered Paper 2

Q&A 13:30-13:35

REFRESHMENT BREAK

Session 2: Gain of function concepts - beyond degradation

Chair: Edward Tate

FLASH TALKS SESSION 1

Amit Choudhary Harvard University, USA

Q&A 14:25-14:35

Proffered Paper 3

Q&A 14:45-14:50

REFRESHMENT BREAK

FLASH TALKS SESSION 2

Proffered Paper 4

Q&A 15:30-15:35

Proffered Paper 5

Q&A 15:45-15:50

Nicolas Thomä EPFL, Switzerland

'Degrading oncogenic transcription factors'

Q&A 16:10-16:20

SUMMARY AND CLOSE

Listed times are in Central European Time (CET)

WELCOME TO DAY TWO

Session 3: Rational design of molecular glues; Enabling technologies; Computational approaches for glue discovery

Chair: Brian Liau

Edward Tate Imperial College London, UK

Q&A 12:25-12:35

Zuzanna Kozicka EPFL, Switzerland

'Chemical entry points into protein degradation'

Q&A 12:55-13:05

Proffered Paper 6

Q&A 13:15-13:20

Proffered Paper 7

Q&A 13:30-13:35

REFRESHMENT BREAK

Session 4: Novel E3 ligases; Protein degradation of membrane proteins

Chair: Sophie Postel-Vinay

FLASH TALKS SESSION 3

Brian Liau Harvard University, USA

'Chemical and Genetic Glues of the E3 Ligase Substrate Adapter KBTBD4'

Q&A 14:25-14:35

REFRESHMENT BREAK

FLASH TALKS SESSION 4

Daniel K Nomura University of California, USA

'Reimagining Druggability using Chemoproteomic Platforms'

Q&A 15:25-15:35

Proffered Paper 9

Q&A 15:45-15:50

DISCUSSION SESSION

Led by the SPC, an informal discussion session where participants are invited to discuss the key talking points from the day

SUMMARY AND CLOSE