Listed times are in Central European Time (CET)

REGISTRATION & WELCOME LUNCH (lunch from 12:00)

WELCOME TO DAY ONE

SESSION 1 - Technologies and Genomics

Chair: Sophie Postel-Vinay

Opening Keynote Lecture

Scott Lowe Memorial Sloan Kettering Cancer Centre, New York, USA

"Understanding and exploiting tumor suppressive programs"

Q&A: 13:45-13:55

Céline Vallot Institut Curie, Paris, France

"Mechanisms of cell plasticity in breast cancers"

Q&A: 14:15-14:25

Mirja Rotinen Public University of Navarre, Pamplona, Spain

Proffered Paper 1: "ONECUT2 is a targetable lineage plasticity modulator of breast cancer that suppresses the estrogen axis"

Q&A: 14:35 - 14:40

EXHIBITOR INTRODUCTIONS

COFFEE BREAK & EXHIBITION

Jean Soulier Hôpital Saint-Louis, INSERM, Paris, France

"Secondary leukemia to stressed hematopoiesis"

Q&A: 15:40-15:50

Renata Basto Institut Curie, Paris, France

"Centrosome amplification induces apoptotic priming and favors the response to chemotherapy in epithelial ovarian cancer beyond multipolar divisions"

Q&A: 16:10-16:20

POSTER SPOTLIGHTS

Valeria Bica, University of Rome "Tor Vergata", Rome, Italy; Oriol de Barrios Barri, Josep Carreras Leukemia Research Centre, Barcelona, Spain; Naoyuki Nishiya, Iwate Medical University School of Pharmacy, Shiwa-gun, Japan

Meet The Expert Session

Yves Pommier, National Cancer Institute, Center for Cancer Research, Bethesda, USA; Céline Vallot, Institut Curie, Paris, France

WELCOME RECEPTION

POSTER DISCUSSION SESSION 1

Listed times are in Central European Time (CET)

EARLY POSTER VIEWING

Session 2: Leukemia Therapy

Chair: Patrick Mehlen

Andreas Trumpp German Cancer Research Centre (DKFZ), Heidelberg, Germany

"MAC-scoring in leukemic stem cells predicts response to Venetoclax in AML patients"

Q&A: 09:20-09:30

Irina Korovina HZDR – Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Proffered Paper 2: "Integrin α2-deficiency reduces treatment resistance in glioblastoma by modulating ATF1 activity"

Q&A: 09:40 - 09:45

Hugues de Thé College de France, Paris, France

"From nuclear architecture to leukemia cure: emerging roles of PML"

Q&A: 10:05-10:15

Yves Pommier National Cancer Institute, Center for Cancer Research, Bethesda, MA, USA

"Genomics and Schlafen 11 (SLFN11) as predictors in oncology clinical trials"

Q&A: 10:35-10:45

COFFEE BREAK & EXHIBITION

Julien Ablain CRCL, Lyon, France

"Investigating the mechanisms of melanoma development and therapy response using zebrafish"

Q&A: 11:35-11:45

Laura Broutier CRCL, Lyon, France

Proffered Paper 3: "Modelling the next-generation of fusion-negative rhabdomyosarcoma 3D-organoids to predict effective drug combinations: a proof-of-concept on cell death inducers"

Q&A: 11:55 - 12:00

POSTER SPOTLIGHTS

Emmanuel Griessinger, Université Côte d'Azur, INSERM, Menton, France; Thi Nhat Uyen Nguyen, Taipei Medical University, Taipei, Taiwan; Sean Rudd, Karolinska Institutet, Solna, Sweden

LUNCH & EXHIBITION

POSTER DISCUSSION SESSION 2

Session 3: Novel Approaches to Drug Sensitivity

Chair: Hugues de The

Sophie Postel-Vinay IGR, Paris, France

"Harnessing genetic vulnerabilities in immuno-oncology: novel therapeutic opportunities"

Q&A: 15:00-15:10

Mattia Marinucci University of Basel, Basel, Switzerland

Proffered Paper 4: "(Phospho)Proteomic analysis reveals vulnerabilities in metastatic colorectal cancer"

Q&A: 15:20 - 15:25

Hyunbin Huh Yonsei, Seoul, South Korea

Proffered Paper 5: "Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination"

Q&A: 15:35 - 15:40

Patrick Mehlen Lyon Cancer Research Center (CRCL), Paris, France

"Targeting netrin-1 in cancer: from mechanisms of cell death to patients"

Q&A: 16:00-16:10

COFFEE BREAK & EXHIBITION

Fanny Jaulin Gustave Roussy, Villejuif, France

"Organoids as tools for functional precision medicine in advanced pancreatic cancer"

Q&A: 17:00-17:10

The EMBO Keynote Lecture

Cedric Blanpain Laboratory of Stem Cells and Cancer, ULB, Brussels, Belgium

"Targeting EMT mediated resistance to therapy"

Q&A: 17:30-17:40

Panel Discussion

Chair: Hugues de The

Sophie Postel-Vinay, IGR, Paris, France; Patrick Mehlen, CRCL, Paris, France; Fanny Jaulin (Gustave Roussy, Villejuif, France

CONFERENCE DINNER

The 3-course dinner will be at the Hotel Crowne Plaza Lyon's restaurant, Antipasto. Optional ticketed event.

Listed times are in Central European Time (CET)

EARLY POSTER VIEWING

Session 4: Metabolism and Senescence

Chair: Sophie Postel-Vinay

Filipe Cabriero MRC London Institute of Medical Sciences, London, UK

"Microbially derived adjuvants for cancer chemotherapy"

Q&A: 09:20-09:30

Jean-Emmanuel Sarry Centre de Recherches en Cancérologie de Toulouse (Oncopole), Toulouse, France

"Metabolic bases of drug resistance in acute myeloid leukemia"

Q&A: 09:50-10:00

Rocio Matesanz Sanchez OncoRay – National Center for Radiation Research in Oncology, Dresden, Germany

Proffered Paper 6: "Targeting exostosin glycosyltransferase 2 (EXT2) modulates glioblastoma cell metabolism, sensitizing to X-ray irradiation via ferroptosis"

Q&A: 10:10 - 10:15

COFFEE BREAK & EXHIBITION

Geraldine Gentric Institut Curie, Paris, France

"Role of stromal heterogeneity in resistance to treatments"

Q&A: 11:05-11:15

Closing Keynote - Clemens Schmitt Max Delbruck Center, Berlin, Germany

"Apoptosis-competent anticancer treatment failure"

Q&A: 11:50-12:00

SUMMARY & CLOSE