Listed times are in Central European Time (CET)

REGISTRATION & WELCOME LUNCH

CONFERENCE WELCOME

Session 1: Targeting organelles for therapy

Chair: Hugues de Thé

OPENING KEYNOTE LECTURE

Anthony Letai Harvard University, USA

"The mitochondrial basis for clinical efficacy of conventional chemotherapy"

Q&A: 13:40-13:55

Maria Rescigno Humanitas University, Italy

"Microbiota in cancer progression and metastasis"

Q&A: 14:15 - 14:25

Martin Higgs University of Birmingham, UK

Proffered Paper 1: "A novel epigenetic mechanism for PARPi resistance in BRCA1-deficient tumour cells"

Q&A: 14:35 - 14:40

EXHIBITOR INTRODUCTIONS

60-second intro pitches by each company

COFFEE BREAK & TRADE

Jean-Emmanuel Sarry (Virtual Presentation) CRCT, France

"Mitochondrial adaptation as a Darwinian mechanism of resistance to drugs in leukemia"

Q&A: 15:40 - 15:50

Poster Spotlights

3 top abstracts presented as 3 minute flash talks

Meet the Expert talk

Jos Jonkers & Maria Rescigno

Prof Jonkers and Prof. Dr. Rescigno will host an informal session where they will both share their own personal and professional experiences of their paths to scientific leadership.

Q&A: 16:30 - 16:45

Welcome Reception

Drinks reception with buffet served from 17:00

POSTER DISCUSSION SESSION 1

Listed times are in Central European Time (CET)

Poster Viewing

Posters may be freely viewed

Session 2: Breast cancer: Old targets, new approaches

Chair: Sandra Demaria

Jason Carroll University of Cambridge, UK

"The role of transcription factors in primary ER+ breast cancer and in metastasis"

Q&A: 09:20 - 09:30

Mathias Dahlmann Max-Delbrück-Center for Molecular Medicine, Germany

Proffered Paper 2: "PDX models as suitable tools to identify response patterns and novel treatment options in highly heterogeneous tumors"

Q&A: 09:40 - 09:45

Cathrin Brisken EPFL, Switzerland

"Taming hormone-sensitive breast cancer"

Q&A: 10:05 - 10:15

Jos Jonkers NKI, Netherlands

"Understanding and overcoming resistance to PARP inhibitors in cancer therapy"

Q&A: 10:35 - 10:45

COFFEE BREAK & TRADE

The EMBO Keynote Lecture

Fatima Mechta-Grigoriou Institut Curie, France

"Role of fibroblast heterogeneity in immunosuppression and resistance to immunotherapy"

Q&A: 11:35-11:45

Stefan Florian Charité University Hospital, Germany

Proffered Paper 3: "Microtubule binding drugs as a phenotype specific targeted cancer therapy"

Q&A: 11:55 - 12:00

Lisa Derosa Institute Gustave Roussy, France

"Targeting Gut and Tumour Microbiota to Increase Cancer Immunotherapy Efficacy"

Q&A: 12:20 - 12:30

POSTER SPOTLIGHTS

3 top abstracts presented as 3 minute flash talks

Lunch

POSTER DISCUSSION SESSION 2

Session 3: New Lives for Chemo

Chair: Sophie Postel-Vinay

Michael Hemann MIT, USA

"What chemotherapy can tell us about tumor cell dependencies"

Q&A: 15:30 - 15:40

INDUSTRY SPOTLIGHT - Standard BioTools

Melissa Klug

"Ready-to-use 45+ flow cytometry marker panels to measure activation, cytokine production and cytotoxicity from <300ul of whole blood"

COFFEE BREAK & TRADE

Maria Secrier UCL Genetics Institute, UK

Proffered Paper 4: "A novel quiescence signature captures rapid drug tolerance development in cancer persister cells"

Q&A: 16:50 - 16:55

Vinu Jose (Virtual Presentation) Institut Jules Bordet - Universite Libre du Bruxelles, Belgium

Proffered Paper 5: "Microtubule targetting agents affect the clinical benefit of immune response in early breast cancer"

Q&A: 17:05 - 17:10

Hugues de Thé Institut Jean Bernard, France

"From nuclear architecture to leukemia cure: emerging roles of PML"

Q&A: 17:30 - 17:40

Conference Dinner

30-minute drinks reception before the dinner at 19:00. Optional ticketed event.

Listed times are in Central European Time (CET)

Poster viewing

Session 4: Exploiting cytoplasmic DNA sensing for therapy

Chair: Sophie Postel-Vinay

Kalle Sipila King's College London, UK

Proffered Paper 6: "Mutational heterogeneity and drug response in oral squamous cell carcinoma"

Q&A: 09:55 - 10:00

Sophie Postel-Vinay Gustave Roussy, France

"Harnessing genetic vulnerabilities in immuno-oncology: novel therapeutic opportunities"

Q&A: 10:20 - 10:30

COFFEE BREAK & TRADE

Priyanka Bhosale Kings College London, UK

Proffered Paper 7: "Apoptosis of tumour infiltrating lymphocytes is a mechanism of tumour resistance in OSCC"

Q&A: 11:10 - 11:15

Olivia Ciampa Garvan Institute of Medical Research, Australia

Proffered Paper 8: "Senescence Reprogramming in ER+ Breast Cancer"

Q&A: 11:25 - 11:30

Closing Keynote Lecture

Sandra Demaria Weill Cornell Medicine, USA

"Cancer cell-intrinsic and extrinsic innate immune activation induced by radiation"

Q&A: 12:00 - 12:15

SUMMARY & CLOSE

Depart