Listed times are in Central European Summer Time (CEST)

REGISTRATION (LIGHT REFRESHMENTS WILL BE SERVED AT 12:00)

CONFERENCE WELCOME

SESSION 1: Cancer - host metabolic communication

Chair: Patricia Altea

KEYNOTE LECTURE

Marcia Haigis Harvard University, USA

'Investigating the role of metabolites in Cancer and Aging'

Q&A 13:40 - 13:55

Ayelet Erez Weizmann Institute of Science, Israel

'Rewiring Hepatic Metabolism Through Tumor–Host Interactions During Cancer Cachexia'

Q&A 14:15 - 14:25

Sara Isabel Fernandes VIB CCB - KU Leuven, Belgium

Proffered Paper 1: 'Methionine restriction inhibits breast cancer metastasis'

Q&A 14:35 - 14:40

MOLECULAR ONCOLOGY CALL FOR CONTENT

Kevin Ryan Molecular Oncology / FEBS

EXHIBITOR INTRODUCTIONS

COFFEE BREAK, EXHIBITION AND SOLO TRAVELLERS' MEET-UP

Salvador Aznar-Benitah IRB Barcelona, Spain

'Endocrine role of metastasis in systemic energy-wasting and cachexia'

Q&A 15:45 - 15:55

Almut Schulze DKFZ, Germany

'Targeting metabolic plasticity and flexibility in cancer'

Q&A 16:15 - 16:25

POSTER SPOTLIGHTS

Giorgia Della Rocca (Italy) 'Mitochondrial GPD2 orchestrates redox adaptation in colorectal cancer and its targeting exposes a vulnerability to LDH blockade and fasting'

Justine Epiney (Switzerland) 'Targeting Long-Chain Fatty Acid Elongation Disrupts Cancer Membranes Organization and Triggers Anti-Cancer Immunity'

Blanca Majem Cavaller (Spain) 'Tumor- and liver-derived ApoE orchestrate an inter-organ lipid transport circuit that fuels metastatic growth, systemic inflammation, and cancer-associated cachexia'

INDUSTRY SPOTLIGHT - Numiera Therapeutics

Led by members of the Scientific Programme Committee

Izi Stoll Numiera Therapeutics

'Repositioning the CPT1 inhibitor etomoxir for the treatment of gliobastoma'

PANEL DISCUSSION - Meet the Expert

WELCOME RECEPTION

POSTER DISCUSSION SESSION 1

Led by members of the Scientific Programme Committee

Listed times are in Central European Summer Time (CEST)

EARLY POSTER VIEWING WITH COFFEE

INDUSTRY SPOTLIGHT - NVision Quantum Technologies

Led by members of the Scientific Programme Committee

Simon Bennett NVision Quantum Technologies

'Visualize Cancer Metabolism - As It Happens'

SESSION 2: Metabolic signalling

Chair: Arkaitz Carracedo

Christian Frezza University of Cologne, Germany

'Tissue-specific responses to fumarate hydratase loss'

Q&A 09:20 - 09:30

Shiran Rabinovich The Francis Crick Institute, UK

Proffered Paper 2: 'Loss of TIGAR in Lung Tumours Promotes Metastasis by Boosting Cholesterol Uptake'

Q&A 09:40 - 09:45

Patricia Altea CABIMER, Spain

'The signaling role of fatty acids in metastasis'

Q&A 10:05 - 10:15

Alpaslan Tasdogan University Hospital Essen, Germany

'Metabolism - The new frontier in melanoma precision medicine'

Q&A 10:35 - 10:45

COFFEE BREAK AND EXHIBITION

George Poulogiannis ICR, UK

'Deciphering the complexities of cancer metabolism for therapeutic gain'

Q&A 11:35 - 11:45

Ivon Angelova University of Cambridge, UK

Proffered Paper 3: 'Dietary Restriction of Serine and Glycine Promotes Anti-Tumour Immunity in Triple-Negative Breast Cancer via cGAS-STING'

Q&A 11:55 - 12:00

POSTER SPOTLIGHTS

Rom Keshet (Israel) 'Tumor-reprogrammed LDL functions as a systemic messenger driving hepatic pre-metastatic niche formation'

Katarzyna Duzowska (Poland) 'Lipid-metabolic reprogramming of the tumor-adjacent tissue is associated with relapse in breast cancer'

Yoav Shaul (Israel) 'Pyrimidine Catabolism Generates Signaling Metabolites that Promote Aggressive Cancer Cell States'

LUNCH

POSTER DISCUSSION SESSION 2

Led by members of the Scientific Programme Committee

SESSION 3: Organelle metabolism

Chair: Lydia Finley

Luca Scorrano UMass Chan Medical School, Italy

'Keeping mitochondria in shape: a matter of cancer cell life and death'

Q&A 15:00 - 15:10

Gilles Rademaker GIGA Cancer, University of Liege, Belgium

Proffered Paper 4: 'PCSK9-driven cholesterol metabolism dictates liver versus lung organotropism in metastatic PDAC'

Q&A 15:20 - 15:25

Marzia Santamaria IFOM, Italy

Proffered Paper 5: 'Fasting induces ferroptosis by modulating lipid metabolism in breast cancer'

Q&A 15:35 - 15:40

Kivanc Birsoy Rockefeller University, USA

'Understanding the role of organellar redox metabolism in physiology and disease'

Q&A 16:00 - 16:10

COFFEE BREAK AND EXHIBITION

Marja Jäättelä University of Copenhagen, Denmark

'Targeting Lysosomes in Cancer Treatment'

Q&A 17:00 - 17:10

EMBO YOUNG INVESTIGATOR LECTURE

Sara Sdelci Centre for Genomic Regulation, Spain

'Chromatin beyond epigenetics: a macromolecular metabolic sponge'

Q&A 17:30 - 17:40

Panel Discussion - The Rapid Implementation of AI in Research

CONFERENCE DINNER (OPTIONAL TICKETED EVENT)

Listed times are in Central European Summer Time (CEST)

EARLY POSTER VIEWING WITH COFFEE

INDUSTRY SPOTLIGHT - Agilent Technologies

Led by members of the Scientific Programme Committee

Alfredo Caro-Maldonado Cell Analysis Field Application Scientist, Agilent Technologies

'Agilent solutions bring you the 3D Cell Analysis with Seahorse, xCELLigence eSight and cytation'

SESSION 4: Lessons learned from metabolism in cancer and beyond

Chair: Ayelet Erez

Lydia Finley MSKCC, USA

'Decoding metabolic signals during cell fate transitions'

Q&A 09:20 - 09:30

Arkaitz Carracedo CIC bioGUNE, Spain

'The influence of cellular and systemic metabolism in prostate cancer progression'

Q&A 09:50 - 10:00

Nicolas Rabas The Francis Crick Institute, UK

Proffered Paper 6: 'A metabolic link connecting cancer primed neutrophils, tissue regeneration and pro-metastatic tissue conditioning'

Q&A 10:10 - 10:15

COFFEE BREAK AND EXHIBITION

The EMBO Keynote Lecture

Sarah-Maria Fendt VIB-KU Leuven Centre for Cancer Biology, Belgium

'Metabolic rewiring driving metastasis formation'

Q&A 11:05 - 11:15

KEYNOTE LECTURE

Jared Rutter University of Utah, USA

'Metabolism and Cellular Decisions'

Q&A 11:45 - 12:00

SUMMARY, AWARDS AND CLOSE