REGISTRATION & WELCOME LUNCH

CONFERENCE WELCOME

SESSION 1: Metabolic wiring in cancers

Chair: Arkaitz Carracedo

Keynote Lecture

Ralph DeBerardinis Children’s Medical Center Research Institute, USA

"Tumor Metabolism and Cancer Progression in Humans"

Q&A: 13:40 - 13:55

Sarah-Maria Fendt VIB Leuven, Belgium

"The role of metabolism in metastasis formation"

Q&A: 14:15 - 14:25

Eva Crosas-Molist Barts Cancer Institute, UK

Proffered Paper 1: "AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin II dependent cell migration"

Q&A: 14:35 - 14:40

EXHIBITOR INTRODUCTIONS

60-second intro pitches by each company

COFFEE BREAK & TRADE

Chair: Sarah-Maria Fendt

Matthew Vander Heiden Koch Institute, MIT, USA

"Metabolic limitations in Cancer"

Q&A: 15:40 - 15:50

Oliver Maddocks University of Glasgow, UK

"Cancer specific amino acid metabolism"

Q&A: 16:10 - 16:20

Arkaitz Carracedo CIC bioGUNE, Spain

"Metabolic drivers of prostate cancer progression beyond the tumor cell"

Q&A: 16:40 - 16:50

POSTER SPOTLIGHTS

Top abstracts presented as 3 minute flash talks by Natividad Alquezar-Artieda CLIP, Czech Republic, Patricia Altea-Manzano KU Leuven, Belgium, and Imanol Arozarena NAVARRABIOMED-FMS, Spain

WELCOME RECEPTION & TRADE EXHIBITION

including drinks and a light buffet

POSTER DISCUSSION SESSION 1

POSTER VIEWING

INDUSTRY SPOTLIGHT 1 - Agilent Technologies

Alfredo Caro-Maldonado

"How to develop and predict the efficiency of T cell therapies by immunometabolism"

SESSION 2: Metabolic programs along cell states

Chair: Christian Frezza

EMBO Keynote Lecture

Massimiliano Mazzone University of Leuven, Belgium

"Harnessing tumor metabolism to overcome immunosuppression"

Q&A: 09:20 - 09:30

Lisa Vettore University of Birmingham, UK

Proffered Paper 2: "Proline biosynthesis through PYCRL regenerates NAD+ to promote cancer stem-like cells proliferation and survival under hypoxic conditions"

Q&A: 09:40 - 09:45

Salvador Aznar Benitah Institute for Research in Biomedicine, Spain

"Epigenetic influence of our (fatty) diet on metastatic-initiating cells"

Q&A:10:05 - 10:15

Theodore Alexandrov European Molecular Biology Laboratory, Germany

"Spatial metabolomics in tissues and single cells"

Q&A: 10:35 - 10:45

COFFEE BREAK & TRADE

KEYNOTE LECTURE

Joshua Rabinowitz Lewis-Sigler Institute for Integrative Genomics, USA

"The energy budget of tumors in vivo"

Q&A: 11:45 - 12:00

Tobias Ackermann CRUK: Beatson Institute

Proffered Paper 3: "Secreted mono-unsaturated fatty acids are paracrine anti-ferroptotic factors in triple-negative breast cancer cells"

Q&A: 12:10-12:15

POSTER SPOTLIGHTS

Top scoring abstracts presented as 3 minute talks from Sarah Cherkaoui (UCH Zurich, Switzerland), Ginevra Doglioni (VIB-KU Leuven, Belgium) & Lorea Valcarcel Jimenez (Hutchison/MRC RC & CECAD, UK).

BUFFET LUNCH & TRADE

POSTER DISCUSSION SESSION 2

SESSION 3: Metabolism beyond the tumor cell

Chair: Sarah-Maria Fendt

Keynote Lecture

Celeste Simon Abramson Family Cancer Research Institute, USA

“Exploring Tumor Neighbourhoods"

Q&A: 15:20 - 15:35

Katrien De Bock ETH Zurich, Switzerland

"Endothelial cells and metabolism in the muscle microenvironment"

Q&A: 15:55 - 16:05

Debbie Moss Queen's University Belfast, UK

Proffered Paper 4: "Oxidative Mitochondrial Metabolism: A Key Driver of Therapy Resistance in Colorectal Cancer"

Q&A: 16:15 - 16:20

Fabricio Loayza-Puch DKFZ, Germany

Proffered Paper 5: "Exploiting mitochondrial translation to uncover compartment-specific metabolic vulnerabilities"

Q&A: 16:30 - 16:35

COFFEE BREAK & TRADE

Sara Zanivan Beatson Institute, UK

"CAF metabolism coordinates extracellular matrix production"

Q&A: 17:25 - 17:35

Ilaria Elia University of Leuven, Belgium

"The metabolic cross-talk between T cells and tumor cells in the tumor microenvironment"

Q&A: 17:55 - 18:05

MEET THE EDITORS

Join us in this informal session to meet Alfredo Gimenez-Cassina (Nature Metabolism), Maria Garcia-Fernandez (Nature Communications) and Barbara Marte (Nature) and ask questions in a relaxed and informal setting. Scheduled to end at 18:45.

CONFERENCE DINNER

Optional ticketed dinner

POSTER VIEWING

INDUSTRY SPOTLIGHT 2 - Parse Biosciences

Mostafa ElMaghraby

"Resolving More Biology Using the Evercode Platform for Single Cell RNA Sequencing"

Meet the Members of the Scientific Programme Committee

This is an opportunity for all participants to get to know, and ask questions to, Arkaitz, Christian, Sarah-Maria and Sara in an informal setting.

SESSION 4: Cancer metabolism and the regulation of the epigenome

Chair: Sara Zanivan

Sonia Rocha Institute of Integrative Biology/Biochemistry, UK

“Chromatin as a metabolic sensor in the cell”

Q&A: 10:05 - 10:15

Andreas Trumpp DKFZ, Germany

"Metabolism in normal and malignant stem cells"

Q&A: 10:35 - 10:45

COFFEE BREAK & TRADE

Alia Ghrayeb Technion-Israel Institute of Technology, Israel

"Glycine ameliorates paracetamol-induced liver injury in non-alcoholic fatty liver disease by supporting glutathione biosynthesis"

Q&A: 11:25-11:30

Andrea Morandi Università di Firenze, Italy

"Lipid droplets-peroxisome metabolic axis is a vulnerability of ER+ breast cancer resistant to estrogen deprivation"

Q&A: 11:50 - 12:00

Katiuscia Bianchi Barts Cancer Institute, UK

"Role of cellular metabolism in obesity-driven breast cancer"

Q&A: 12:20 - 12:30

Conference Summary

DEPART