Registration

Main Concourse

Tea/coffee & biscuits will be available 15:00 - 17:00

Conference Welcome

Wolfson Hall

Scientific Programme Committee

Chair: Carlos Caldas

Keynote Lecture

Gad Getz Broad Institute, USA

"Coding and Non-Coding Drivers in Cancer"

Networking Reception

The Buttery

Welcome Dinner

Dining Hall

All participants are invited to join this seated two course dinner.

POSTER VIEWING

Main Concourse and Jock Colville Hall

Session 1: Mutations and mutational processes in cancer

Chair: Yardena Samuels

David Adams Wellcome Trust Sanger Institute, UK

"Germline MC1R variants and somatic mutation burden in melanoma"

Francesca Ciccarelli The Francis Crick Institute, UK

"Inherited vulnerabilities and the onset of multiple colorectal cancers"

Exhibitor Introductions

Wolfson Hall

COFFEE BREAK & TRADE EXHIBITION

Rajbir Nath Batra CRUK Cambridge Institute, UK

Proffered Paper 1: "Decoding the regulatory role and epiclonal dynamics of DNA methylation in breast cancer using sequencing-based profiling of 1482 breast tumours"

Stefan Dentro Sanger Institute, UK

Proffered Paper 2: "Pervasive intra-tumour heterogeneity and subclonal selection across cancer types"

Núria Lopez-Bigas IRB Barcelona, Spain

"Coding and non-coding cancer mutations"

SATELLITE SYMPOSIUM 1: NanoString Technologies

Wolfson Hall

Julia Kargl Medical University of Graz, Austria

“A 3D Biology™ view of cancer: Simultaneous detection of somatic DNA mutations and expressed fusion transcripts plus expression profiling of phospho and total signalling proteins from lung-tumor FFPE samples”

LUNCH

Dining Hall

POSTER DEFENCE SESSION 1 & TRADE EXHIBITION

Main Concourse and Jock Colville Hall

Tea/coffee will be available 15:00 - 15:30.

Poster Spotlight Session

Spotlight Area (opposite registration desk)

3 top-scoring abstracts with be presented on a TV screen.

Session 2: Liquid biopsies in cancer

Chair: James Brenton

Caroline Dive CRUK Manchester Institute, UK

"Molecular analysis of circulating tumour cells in lung cancer"

Nicholas Turner ICR, UK

"Predicting Relapse Using Circulating Tumor DNA in Breast Cancer"

Jelena Belic Medical University of Graz, Austria

Proffered Paper 3: "Detection and characterization of neuroendocrine prostate cancer using whole genome-sequencing in circulating tumor DNA"

Michael Speicher Medical University of Graz, Austria

"Inferring expressed genes by whole-genome sequencing of plasma DNA"

Eran Kotler Weizmann Institute of Science, Israel

Proffered Paper 4: "A comprehensive library of systematically designed p53 variants elucidates patterns of evolutionary conservation and of mutations in human tumors"

High Tea & Discussion Forum

An opportunity for participants to converse with speakers in small groups.

POSTER VIEWING & TRADE EXHIBITION

Main Concourse and Jock Colville Hall

Session 3: Genomics and immune landscapes in cancer (I)

Chair: James Brenton

Ido Amit Weizmann Institute of Science, Israel

"The power of ONE: Immunology in the age of single cell genomics"

Sergio Quezada UCL, UK

"Mapping the immune and antigenic landscape of cancer"

COFFEE BREAK & TRADE EXHIBITION

Eva Bräunlein TU Munich, Germany

Proffered Paper 5: "In-depth characterization of immune responses against neoepitopes from primary melanoma tissues identified by mass spectrometry"

Marian Burr Peter MacCallum Cancer Centre, Australia

Proffered Paper 6: "CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity"

Yardena Samuels Weizmann Institute of Science, Israel

"Comprehensive elucidation of the antigenic and T cell melanoma landscapes reveal them to be restricted and oligoclonal"

SATELLITE SYMPOSIUM 2: Lucigen

Wolfson Hall

Rob Brazas Lucigen Corporation, USA

“Overcoming the Challenges of Illumina DNA Library Prep”

LUNCH

Dining Hall

POSTER DEFENCE SESSION 2 & TRADE EXHIBITION

Main Concourse and Jock Colville Hall

Tea/coffee will be available 15:00 - 15:30.

POSTER SPOTLIGHT SESSION

Spotlight Area (opposite registration desk)

3 top-scoring abstracts with be presented on a TV screen.

Session 4: Genomics and immune landscapes in cancer (II)

Chair: Carlos Caldas

Carlos Caldas CRUK Cambridge Institute, UK

"Clonal and cellular heterogeneity landscapes of breast cancer"

Chris de Witte UMC Utrecht, Netherlands

Proffered Paper 7: "Establishment and characterization of an ovarian cancer organoid biobank"

Keynote Lecture

Ton Schumacher NKI, Netherlands

"T cell recognition in human cancer"

Conference Dinner

Dining Hall

All participants are invited to enjoy a three-course dinner together on the final evening of the conference. Award certificates will be presented during this event.

Last chance to view posters

(removed by 13:00)

Session 5: Precision cancer medicine

Chair: Carlos Caldas

James Brenton CRUK Cambridge Institute, UK

"Precision medicine for high-grade serous ovarian cancer"

Caitlin A. Nichols Dana-Farber Cancer Institute, USA

Proffered Paper 8: "Loss of heterozygosity of essential genes represents a novel class of cancer vulnerabilities"

Alejandra Bruna CRUK Cambridge Institute, UK

Proffered Paper 9: "Interrogating the role of breast cancer functional heterogeneity in a tumour’s evolutionary trajectory upon therapeutic pressure using PDTX models"

René Bernards NKI, Netherlands

"Finding vulnerabilities of drug-resistant cancer"

COFFEE BREAK

Charles Swanton The Francis Crick Institute, UK

"Chromosomal Chaos and Order in Cancer Evolution: TRACERx"

Keynote Lecture

Olli Kallioniemi SciLifeLab, Sweden

"Patient-derived primary cancer cells, integrative omics and functional drug testing facilitating precision cancer medicine"

Closing Remarks

Scientific Programme Committee

LUNCH & DEPART