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Europe’s membership association for cancer researchers

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Image of the Month: January 2017

The EACR Image of the Month highlights both scientifically and visually stimulating cancer research images from EACR members.

We are pleased to announce our January 2017 Image of the Month winner: Our congratulations go to Brooke Pereira for sending this complex and layered image representing a 3D melt electrospun scaffold model of the human prostate tumour microenvironment.

We wish to thank our panel of reviewers for their help in selecting the winning image.

Do you have a scientific image you’d like to share? Please visit our Image of the Month page to find out how to submit your image.

Winner: 3D melt electrospun scaffold model of the human prostate tumour microenvironment

This image is representative of a 3D melt electrospun scaffold model of the human prostate tumour microenvironment, which incorporates primary cancer-associated fibroblasts (CAF) and benign epithelial cells (BPH-1). The primary CAFs (rhodamine phalloidin - red) are first seeded onto the scaffold where they proliferate and deposit native extracellular matrix (ECM; fibronectin - cyan), resulting in neo-microtissue formation. After this, BPH-1 cells stained with CellTracker Green are co-cultured on top of the microtissue construct. After 24 hours, morphological transformation of the BPH-1 cells is observed, as they take on an elongated and spindle-like shape, indicating early malignant transformation.

Submitted by: Brooke Pereira, PhD Student, Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute (BDI), Monash University, Melbourne, Australia.

03 Jan 2017

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