Protecting the Code: Epigenetic Impacts on Genome Stability

Berlin, Germany : 29 October - 1 November 2017

Scientific Programme

Sunday 29th October 2017

15:30

Registration

Planck Lobby

Coffee and tea will be available

17:00

Welcome and introduction

Scientific Programme Committee

17:15

Keynote Lecture 1

Akira Yasui Tohoku University, Japan

"Histone modification and nucleosome remodeling regulating transcription and DNA repair"

18:15

Speed Networking

Planck Lobby

19:00

Welcome buffet

Meitner Saal

Trade exhibition opens

Monday 30th October 2017

08:30

Poster Preview

Meitner Saal

Coffee and tea will be available.

09:00

Session 1: Chromatin remodelers and DNA damage

Chair: Susan Gasser

Claudia Lukas NNF CPR, Denmark

"The role of DNA replication stress in cell fate decisions after whole-genome duplication"

09:30

Niels Mailand NNF CPR, Denmark

"Regulation of chromatin ubiquitylation in the DNA damage response"

10:00

Aaron Goodarzi University of Calgary, Canada

Proffered Paper 1: "The CHD6 chromatin remodeler is an oxidative stress-induced DNA damage response factor"

10:15

Exhibitor Introductions

A fun session to introduce the companies who are exhibiting at the conference.

10:25

COFFEE BREAK & TRADE EXHIBITION

Meitner Saal

11:00

Boris Pfander Max Planck Institute of Biochemistry, Germany

Proffered Paper 2: "Chromatin constitutes a bottleneck in the response to double strand breaks"

11:15

Jessica Downs ICR, UK

"The PBAF chromatin remodelling complex and maintenance of genome stability"

11:45

Satellite Symposium: Chromatrap

12:15

Lunch

Liebig Vault Restaurant

Hot buffet lunch with seating available

13:00

POSTER DEFENCE SESSION 1 & TRADE EXHIBITION

Meitner Saal

Odd numbered posters (1,3,5 etc) will be presented in this session.

14:30

Session 2: Propagating the epigenome

Chair: Jo Morris

Iestyn Whitehouse MSKCC, USA

"Coupling of genes and replication origins"

15:00

Christopher Douse University of Cambridge, UK

Proffered Paper: "Molecular mechanisms of transgene silencing by the Human Silencing Hub (HUSH) and MORC2"

15:15

Kyle Miller University of Texas at Austin, USA

Proffered Paper 3: "Bromodomain proteins: Readers of Genome Integrity"

15:30

Kristijan Ramadan University of Oxford, UK

"Ubiqutin dependent ATPase p97 and deubiquitinating enzyme X (DUBX) regulate DNA damage response after ionising radiation"

16:00

Round Table Discussions

Einstein Lounge

Beverages are available to purchase from the bar.

17:30

Free evening to explore Berlin

Tuesday 31st October 2017

08:30

Poster Preview

Meitner Saal

Coffee and tea will be available.

09:00

Meet the Expert

Penny Jeggo University of Sussex, UK

An interactive session where Prof. Jeggo will share from her personal perspective and experiences. There will be a chance to ask your questions.

Session 3: DNA damage repair

Chair: Iestyn Whitehouse

09:30

Haico van Attikum LUMC, Netherlands

"Regulation and dynamics of DNA repair in a chromatin context"

10:00

Jacques Cote Université Laval, Canada

Proffered Paper 4: "Phospho-dependent recruitment of NuA4 by MRX at DNA breaks regulates RPA dynamics during resection"

10:15

Ulrich Rass Friedrich Miescher Institute, Switzerland

Proffered Paper 5: "Helicases and nucleases determining replication fork recovery or demise, and implications for genome stability and human disease"

10:30

COFFEE BREAK & TRADE EXHIBITION

Meitner Saal

11:00

Brendan Price Dana-Farber Cancer Institute, USA

"Constructing specialized, acetylated chromatin domains to promote DSB repair"

11:30

Jo Morris University of Birmingham, UK

"The SUMO bomb in DNA double-strand break repair"

12:00

Amélie Fradet-Turcotte Université Laval, Canada

Proffered Paper 6: "A new class of ubiquitylated-histone readers involved in the response to DNA damage"

12:15

Lunch

Liebig Vault Restaurant

Hot buffet lunch with seating available

13:00

POSTER DEFENCE SESSION 2 & TRADE EXHIBITION

Meitner Saal

Even numbered posters (2,4,6 etc) will be presented in this session.

14:30

Session 4: Chromatin and disease states

Chair: Penny Jeggo

Tim Humphrey University of Oxford, UK

"Histone H3K36 trimethylation, genome stability and cancer"

15:00

Ashby Morrison Stanford University, USA

Proffered Paper 7: "Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis"

15:15

Fabrizio d'Adda di Fagagna IFOM, Italy

"DNA damage response activation in cancer and the role of non coding RNAs"

15:45

Keynote Lecture 2

Geneviève Almouzni Institute Curie, France

"Shaping chromatin in the nucleus, the bricks and the architects"

19:30

Drinks Reception & Conference Dinner

Join us for a drink in the Planck Lobby, followed by the Conference Dinner in Liebig Vault. This is an optional event with a limited number of tickets available.

Wednesday 1st November 2017

09:00

Session 5: Chromatin remodelers at the transcription / replication interface

Chair: Jessica Downs

Manolis Papamichos-Chronakis Newcastle University, UK

"INO80 chromatin remodeller links RNA quality control to transcriptional regulation"

09:30

Philipp Oberdoerffer National Cancer Institute, USA

"Replication stress in chromatin: getting fragile sites in shape"

10:00

Andrew Wood IGMM Edinburgh, UK

Proffered Paper 8: "Imprinted genes as a model system to study the impact of chromatin on targeted mutagenesis"

10:15

COFFEE BREAK

Meitner Saal

10:45

Sophie Polo Epigenetics and Cell Fate, France

Proffered Paper 9: "Epigenome maintenance in response to DNA damage"

11:00

Gaëlle Legube CBI Toulouse, France

"Chromatin and chromosome dynamics following DNA Double Strand Break"

11:30

The EMBO Keynote Lecture

Susan Gasser FMI, Switzerland

"Remodelers in response to DNA damage"

12:15

Closing Remarks & Presentation of Awards

Scientific Programme Committee

12:30

Lunch & depart

Planck Lobby

A packed lunch will be provided

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