Mechanisms to Therapies: Innovations in Cancer Metabolism

Bilbao, Spain : 9 - 11 October 2018

Scientific Programme

Tuesday 9th October 2018

08:00

Registration

08:45

Conference Welcome

Scientific Programme Committee

09:00

Opening Keynote Lecture

Bill Kaelin Dana-Farber Cancer Institute, USA

"The VHL Tumor Suppressor Protein:  Insights into Oxygen Sensing, Cancer Metabolism and Drugging the Undruggable"

Session 1 - Oncogenic metabolic signalling

10:00

Brendan Manning HSPH, USA

"The PI3K-mTOR Signaling Network and the Control of Anabolic Cell Growth"

10:40

Author to be selected

Proffered Paper 1

11:00

COFFEE BREAK

11:20

Alejo Efeyan CNIO, Spain

"Oncogenic Nutrient Signaling in B cell Lymphoma"

12:00

Reuben Shaw Salk, USA

Title to be announced

12:40

LUNCH - Meet the expert

Session 2 - Metabolic wiring in cancer

14:20

Navdeep Chandel Northwestern University, USA

"Mitochondria and Cancer"

15:00

Sara Fendt VIB Center for Cancer Biology, Belgium

"Cancer metabolism during metastasis formation"

15:40

Author to be selected

Proffered Paper 2

16:00

COFFEE BREAK

16:20

Ayelet Erez Weizmann Institute of Science, Israel

"The role of amino-acid metabolism in carcinogenesis"

17:00

Matt Vander Heiden Massachusetts Institute of Technology, USA

"How metabolisum supports tumour progression"

17:40

Author to be selected

Proffered Paper 3

18:00

Free evening to enjoy Bilbao!

Wednesday 10th October 2018

Session 3 - Metabolic control of the epigenome

09:00

Raul Mostoslavsky Harvard Medical School, USA

"Linking epigenetics, metabolism and cancer: SIRT6 provides new clues"

09:40

Lydia Finley Memorial Sloan Kettering Cancer Center, USA

"Metabolic coordination of p53-dependent tumor suppression"

10:20

Author to be selected

Proffered Paper 4

10:40

COFFEE BREAK

11:00

Christian Frezza University of Cambridge, UK

"Fumarate hydratase and renal cancer: oncemetabolites and beyond"

11:40

Marcia Haigis Harvard Medical School, USA

"Metabolic Waste and Cancer"

12:20

Author to be selected

Proffered Paper 5

12:40

LUNCH & POSTER VIEWING

Session 4 -Metabolic heterogeneity & tumour progression

14:20

Salvador Aznar-Benitah IRB Barcelona, Spain

"Metastasis-initiating cells: an epigenetic link between between metastasis and what we eat"

15:00

Arkaitz Carracedo CIC bioGUNE, Spain

"Metabolic plasticity in the ever-changing tumor environment"

15:40

Author to be selected

Proffered Paper 6

16:00

COFFEE BREAK

16:20

Carla Martins MRC Cambridge, UK

"Exploiting the metabolic heterogeneity of mutant Kras lung tumors to improve targeting"

17:00

Author to be selected

Proffered Paper 7

17:20

Round Table Discussions

Engage with invited speakers in small groups where you can ask questions and converse informally.

20:30

Conference Dinner

Kafe Antzokia

Thursday 11th October 2018

Session 5 - Targeting stroma metabolism

09:00

Celeste Simon University of Pennsylvania, USA

"Metabolism, Inflammation, and Tumor Progression"

09:40

Peter Carmeliet VIB-KU Leuven Center for Cancer Biology, Belgium

"Angiogenesis revisited: Role and (therapeutic) implication of endothelial metabolism"

10:20

Author to be selected

Proffered Paper 8

10:40

COFFEE BREAK

11:00

Sue Kaech Yale University School of Medicine, USA

"Anti-tumor T cells- you are what you eat"

11:40

Marina Kreutz University of Regensburg, Germany

"Warburg meets immunology: Immunomodulation by lactic acid"

12:20

Author to be selected

Proffered Paper 9

12:40

LUNCH & POSTER VIEWING

Session 6 - Bench to bedside/ Targeting metabolic liabilities

14:00

Ralph Deberardinis UT Southwestern Medical Center, USA

"Understanding metabolic heterogeneity in human cancer"

14:40

Alec Kimmelman NYU Langone Medical Center, USA

"Identifying Metabolic Dependencies in Pancreatic Cancer"

15:20

Author to be selected

Proffered Paper 10

15:40

COFFEE BREAK

16:00

Scott Biller Agios, USA

Title to be announced

16:40

Closing Keynote Lecture

Karen Vousden The Crick Institute, UK

"Serine metabolism and cancer – new therapeutic opportunities"

17:20

Closing Summary

Scientific Programme Committee

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